Please login to the form below

Not currently logged in
Email:
Password:

ARBs link to cancer risk to be investigated

The EMA has launched an investigation into a potential increased risk of cancer in patients taking common blood pressure medicines known as ARBs

The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has launched an investigation into a potential increased risk of cancer in patients taking common blood pressure medicines known as angiotensin-receptor blockers (ARBs).

The investigation was prompted by a meta-analysis published in The Lancet Oncology earlier this month in which nine trials involving 95,000 patients suggested that the drugs may be linked with "a modestly increased risk of new diagnoses of cancer when compared with placebo or other heart medicines."

The study showed that patients randomised to receive ARBs had a 7.2 per cent risk of developing a new cancer over four years, compared to a 6 per cent risk among patients in control groups. But the researchers noted: "it is not possible to draw conclusions about the exact risk of cancer associated with each particular drug."

In the meta-analysis, 86 per cent of patients received Boehringer Ingelheim's Micardis (telmisartan). Other drugs in the class include Merck's Cozaar (losartan), AstraZeneca's Atacand (candesartan cilexetil), Novartis' Diovan (valsartan), sanofi-aventis and Bristol-Myers Squibb's Avapro (irbesartan), Daiichi Sankyo's Benicar (olmesartan), and Solvay's Teveten (eprosartan).

The EMA reported that the panel will review the results as well as any other available data to determine whether changes should be made to the product information or if risk-management plans are necessary for this class of drug.

28th June 2010

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Publicis Resolute

Publicis Resolute provides real-life practical solutions to your issues, without fuss or fluff. We are an experienced team with a...

Latest intelligence

NHS medicines optimisation milestone
Steve How, Paul Midgley and Oli Hudson, of the Wilmington Healthcare Consulting Team, explore the implications of Adalimumab’s recent European patent expiry...
Marketing to healthcare professionals – what’s the key ingredient missing from most campaigns?
What do you think is the difference between a campaign developed to win a share-of-mind with consumers and a campaign designed to gain the attention of healthcare professionals?...
What everyone forgets about good organisational change in pharma
Natasha Cowan speaks to Daphne Chung, Head of Organisational Transformation, to learn how she ensures smooth organisational change that takes all stakeholders into account....

Infographics