Please login to the form below

Not currently logged in
Email:
Password:

Bacteria may lead to antimicrobial drugs

New methods of tackling E.coli, salmonella and brucella infections could be found now that scientists have discovered how some bacteria act to protect themselves

New methods of tackling E.coli, salmonella and brucella infections could be found now that scientists have discovered how some bacteria act to protect themselves when they are threatened or under attack.  

The findings are the culmination of 25 years of studies, led by Professor Ian Booth at the University of Aberdeen and Dr Tarmo Roosild at Nevada Cancer Institute in Las Vegas. The team has worked out the mechanics of 'channels' in bacteria, which stay shut if all is normal and are triggered to open in defence situations.

The breakthrough finding, published in the journal, Structure, could also be used in the fight against the bacteria Pseudomonas, which often colonises the lungs of cystic fibrosis patients and causes infection in those whose immune systems are compromised.

Professor Booth collaborated with Nevada Cancer Institute and the Salk Institute in San Diego, California on the research, which received funding from the Wellcome Trust.

The research focused on E.coli but the protective channel system is common to many pathogens that cause infection and disease.

Professor Booth said: "It is tremendously exciting to have made this breakthrough in understanding the molecular workings of these protective channels that are found in several pathogens, many of which are increasingly resistant to traditional antibiotics."

"Our next challenge is to design chemicals that fool the bacterium into locking the channel open all the time, which will then impair its growth, or we could lock it shut so it can't protect itself."

Dr Roosild added: "Discovery of new drugs through the structural analysis of proteins that underlie diseases, including cancer, and are potentially molecular targets for therapeutic intervention, is the primary focus of our research."

"The hope is that these particular studies will eventually lead to the development of new medicines that will cure people with deep seated bacterial infections such as those in intensive care."

10th June 2009

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
bmore group

OUR PROMISE: BETTER HEALTH FROM TRIAL TO TREATMENT.We are a full service, independent network of specialist agencies under one roof....

Latest intelligence

World Pancreatic Cancer Day 2018: Combating misconceptions in pancreatic cancer
Patients diagnosed with pancreatic cancer face a dismal prognosis, with the disease having the lowest survival rate of all major cancers. In spite of this, pancreatic cancer research is chronically...
World Diabetes Day: Interaction and impact of diabetes on mental health
For World Diabetes Day on the 14th November 2018, Nisha Shahrukh - Medical Writer at Mednet Group has written an article depicting the impact diabetes has on mental health. Including...
EU
Innovation in merger control and the impact on the pharmaceutical sector
Is focusing on pipeline products enough to assess regulatory risks?...

Infographics