Please login to the form below

Not currently logged in
Email:
Password:

Biogen/ Vernalis call halt to Parkinson's drug

Biogen and Vernalis are discontinuing development of the drug vipadenant for Parkinson's disease, due to "findings in preclinical toxicology studies"

Biogen and Vernalis are discontinuing development of the drug vipadenant for Parkinson's disease, although it achieved positive results in phase II studies, due to "findings in preclinical toxicology studies". However, work on a next-generation compound is likely to go into phase 1 studies in early 2011.

Biogen will continue to fund all development costs under the collaboration and Vernalis said it can earn milestones and royalties on the successful development of the next-generation compound, "to the extent that milestones have not already been paid for vipadenant".

Vipadenant is an adenosine A2A receptor antagonist. Experts believe that A2A receptor antagonists could have advantages over conventional dopaminegic strategies. They may be able to help restore motor function in patients with Parkinson's disease, without the side effects, such as nausea and dyskinesia (uncontrolled movement), associated with current treatments.

Vipadenant is one of a small number of adenosine A2A receptor antagonists currently in development by major pharmaceutical companies and their partners.

From their London headquarters, Vernalis's chief executive, Ian Garland said that they were "of course, disappointed" about vipadenant, but hopes are still high for its novel A2A receptor antagonist programme with a next-generation Vernalis compound.

19th July 2010

Share

PMEA Awards 2020

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Windrose Consulting Group

Windrose Consulting Group helps life science companies maximize the commercial value of their products and bring new innovations to market...

Latest intelligence

reaching HCPs during pandemic
Reaching patients and HCPs during the pandemic
COVID-19 has caused unprecedented disruption to drug launches, but some pharma companies avoided costly delays by quickly pivoting to digital channels...
#DemandDiversity: Black history in clinical trials: It's more than just Tuskegee [Infographic]
Take a look at this infographic showing some of the most notorious clinical trials and medical research in history....
Looking back at the year when everything changed
COVID-19 has impacted every aspect of our lives, from the way we shop for groceries to the way we conduct work and interact with healthcare providers and our families....

Infographics