Please login to the form below

Not currently logged in
Email:
Password:

Boehringer/Lilly's Jardiance hits the mark in pivotal heart failure trial

Drug reduced risk of death/hospitalisation in patients with and without diabetes

logos

Boehringer Ingelheim and Eli Lilly’s heart failure drug Jardiance reduced the risk of cardiovascular death or hospitalisation due to heart failure in adult patients with and without diabetes – an important milestone for the drug.

The EMPEROR-Reduced trial evaluated SGLT2 inhibitor Jardiance (empagliflozin) in patients with heart failure with reduced ejection fraction (HFrEF). The drug met the primary endpoint of reduction in death and hospitalisation in this patient population, which opens up a significant market for the drug.

Currently, Jardiance is indicated to lower blood sugar in adults with type 2 diabetes, as well as to reduce the risk of cardiovascular death in adults with type 2 diabetes who have known cardiovascular disease.

Although Boehringer/Lilly did not reveal the full results from the trial, the positive results will no doubt help to build the strength of Jardiance in the heart failure market, which is becoming increasingly competitive.

This includes AstraZeneca’s Farxiga (dapagliflozin), which became the first drug in the SGLT2 inhibitor class to be approved in the US to reduce the chance of hospitalisations, in adults with type 2 diabetes and other cardiovascular risks.

Earlier this week, AZ also touted results for Farxiga in kidney disease, after the drug reduced kidney disease progression in a phase 3 trial of patients with chronic kidney disease (CKD).  In March, the US Food and Drug Administration (FDA) gave Jardiance an accelerated review to reduce kidney disease progression and cardiovascular death in patients with CKD.

For Boehringer/Lilly, the results from the EMPEROR-Reduced trial are an important win given that Jardiance is  entering its last few years of patent life. Last year, Jardiance revenue reached $944.2m – an increase of 43% compared to the full year 2018.

Aside from the EMPEROR-Reduced trial, Boehringer/Lilly is also investigating Jardiance as a treatment in patient with heart failure with preserved ejection fraction (HFpEF)

"With these positive top-line results from the EMPEROR-Reduced trial, we are excited to mark another important advancement for Jardiance," said Mohamed Eid, vice president, clinical development & medical affairs, cardio-metabolism and respiratory medicine at Boehringer Ingelheim.

"There is an urgent need for new heart failure treatments, and these results show promise for the potential role Jardiance can play in improving the lives of adults living with this condition," he added.

Article by
Lucy Parsons

30th July 2020

From: Research

Share

Tags

PMEA Awards 2020

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Videum Health

Videum Health is a premium video platform that offers brands innovative engagement strategies to reach targeted healthcare audiences on a...

Latest intelligence

2020 - a year to remember or forget?
2020 and the Covid pandemic brought immense challenges, and the need for change felt like it happened overnight. What have we learned and what does the future of agency working...
Gilead Headquarters
The search for effective drug treatments for COVID-19
PME talks to Julian Cole, Senior Director, Medical Affairs at Gilead Sciences...
PME Jan cover
AstraZeneca’s focus on diagnosing and managing chronic kidney disease
People living with chronic kidney disease are in urgent need of new and improved approaches to diagnosis and care...

Infographics