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Collaboration on stroke therapy

NeuroVive Pharmaceutical and to-BBB are to work together to develop therapies for stroke and other acute neurodegenerative diseases

Swedish drug company, NeuroVive Pharmaceutical and Dutch biotech to-BBB are to work together to develop therapies for stroke and other acute neurodegenerative diseases.

NeuroVive Pharmaceutical is engaged in research and development of nerve cell-protecting and regenerative cyclosporin-based pharmaceuticals for the treatment of traumatic brain injuries (TBI) and other neurological diseases, while to-BBB works in the field of enhanced drug delivery across the blood-brain barrier.

"The collaboration with to-BBB opens up the possibility of treating brain disorders beyond TBI. There is a tremendous unmet medical need in treating patients with acute neurodegeneration such as stroke, cardiac-arrest-induced brain damage and spinal cord injuries, where one can expect the blood-brain barrier (BBB) to significantly prevent drug penetration to the central nervous system (CNS)," said Dr Eskil Elmer, CSO of NeuroVive.

Pieter Gaillard, CSO of to-BBB, added: "The BBB is indeed a significant obstacle in the treatment of CNS disorders. to-BBB's proprietary G-Technology can safely enhance drug delivery to the brain and we are excited to address this with NeuroVive's cyclosporin-based pharmaceuticals."

Mikael Brönnegård, CEO of NeuroVive, said: "Currently there are no approved pharmacological or cellular primary neuroprotective treatments for stroke and spinal cord injuries. Consequently, the need to develop treatment for acute degenerative disorders has never been greater than it is today. The deal with to-BBB has the potential to generate drugs for large markets in CNS diseases such as stroke."

NeuroVive will fund the initial development up to preclinical Proof of Concept, after which the two companies will develop and commercialise the product jointly. 

25th October 2010

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