Please login to the form below

Not currently logged in
Email:
Password:

Early end for AZ zibotentan study

AstraZeneca has announced an early end to its phase III trial investigating zibotentan in prostate cancer patients due to negative results from an efficacy review

AstraZeneca (AZ) has announced an early end to its phase III trial investigating zibotentan in prostate cancer patients due to negative results from an efficacy review.

The trial, which studied the effectiveness of zibotentan by itself in patients with non-metastatic castrate-resistant prostate cancer (CRPC), was halted after a review from an independent data monitoring committee indicated the drug was unlikely to meet its primary efficacy endpoints concerning progression free survival and overall survival.

A previous trial by AZ investigating zibotentan had already been stopped after negative results were recorded for use of the drug in men with CRPC that had metastasised. Both studies are part of the ENTHUSE programme.

A separate trial in the ENTHUSE programme, investigating the use of zibotentan in combination with chemotherapy in patients for whom the disease has metastasised, is set to continue. Results are expected in the second half of 2011.

The discontinuation of the trial follows the decision by the US Food and Drug Adminstration to deny approval for AZ's potential acute coronary syndrome therapy Brilinta (ticagrelor).

AZ also reported a decrease in profit of two per cent for the fourth quarter of 2010 in recent financial results.

7th February 2011

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Health Unlimited

Health Unlimited is a global health consultancy and communications agency built by specialists with unmatched experience, perspective and expertise. For...

Latest intelligence

Products come and go, but a pharma company’s most valuable, durable asset is its reputation, writes Duncan Mackenzie-Reid and Simon Grist
...
Erik
A quest for innovative solutions
UCB looks to the future through a PRISM...
Big data, privacy and the rise of genomic testing
Blue Latitude Health speaks to Johan Christiaanse, Marketing Director at BGI, to find out how the medical profession can overcome one of the major barriers to precision medicine – big...

Infographics