Please login to the form below

Not currently logged in
Email:
Password:

Forest diabetes drug study fails

Forest's neuropathic pain drug, radiprodil, has missed its primary endpoint in a phase II study

Radiprodil (RGH-896), in development by Forest Laboratories for the treatment of neuropathic pain associated with diabetic peripheral neuropathy missed its primary endpoint in a phase II study compared to placebo.

Forest and its partner on the drug, Gedeon Richter, said that they have not yet made a determination about whether to continue development of the product, but will do so in the coming weeks after reviewing the complete study database.

The drug is part of a wider development partnership signed between Forest and Budapest, Hungary-based Richter in 2005. The agreement gave Forest exclusive rights to the product in the US and Canada in return for undisclosed upfront and milestone payments, research funding and royalties.

Radiprodil targets a specific portion of the NMDA receptor that may be involved in the transmission of pain, an approach that the companies hoped would yield improvements in efficacy and the side effect profile compared to currently available treatments.

However, top-line results from the phase II dose-response trial failed to show statistically significant or clinically meaningful reductions in mean daily pain scores compared to placebo, which was the study's primary endpoint. The 14-week study enrolled about 450 patients.

Forest and Richter are also developing radiprodil for other chronic neuropathic pain conditions.

29th June 2010

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Merrill Brink International

Merrill Brink International is a leading provider of life sciences, legal, financial, manufacturing and corporate language solutions for global companies....

Latest intelligence

OPEN Health delivers over 250 virtual activities during COVID-19 – A clear path forward
...
Can eLearning improve patient recruitment and retention?
Some patients will still want to read pages of informed consent forms before joining a clinical trial, or want timely updates on paper rather than a notification on their phone....
How Far Do You Want To Go?
Join OPEN Health's virtual careers event on Tuesday 10th November, 15:00–17:00 GMT and discover where a career in medical communications could take you…...

Infographics