Please login to the form below

Not currently logged in

GSK launches first-in-class epilepsy drug

GSK introduces Trobalt for the adjunct treatment of adults with partial-onset seizures

GlaxoSmithKline (GSK) has launched Trobalt (retigabine), the first in a new class of anti-epileptic drug (AED), for the adjunct treatment of adults with partial-onset seizures, and demonstrated significant effects in a treatment resistant patient population.

Retigabine is the first AED to target neuronal potassium channels, which are involved in inhibitory mechanisms in the brain. Inhibitory mechanisms are thought to have a role in seizure control.

Professor Martin J Brodie, director of the epilepsy unit at Western Infirmary, Glasgow, UK, said: "Trobalt represents a positive addition to the therapeutic armamentarium for the many adult patients with inadequately-controlled focal onset seizures."

The efficacy and safety of retigabine was established in two pivotal multicentre, randomised, double-blind, placebo-controlled, fixed dose studies where patients who were treatment resistant were recruited. Retigabine significantly improved seizure control, with a greater number of patients achieving a reduction in the number of seizures by 50 per or more, compared with placebo.

Retigabine, referred to as ezogabine in the US, is being jointly developed by GSK and Valeant.

17th May 2011


Featured jobs

Subscribe to our email news alerts


Add my company

Specialising in medical device market research, our approach is people-centric and we thrive on making connections with clients and research...

Latest intelligence

Waking the sleeping giant
The lights are coming on for healthcare delivery in Africa...
How to get rep buy-in for multi-channel
How do you manage a team who may be resistant to change?...
Blog: Digital therapeutics: within our reach?
Digital therapeutics is a hot topic right now. By using digital technology to manage, treat or even prevent chronic conditions, digital therapeutics is promising to revolutionise healthcare. But is this...