Please login to the form below

Not currently logged in
Email:
Password:

Iron chelation may improve survival in MDS

Iron chelation therapy may significantly improve overall survival in heavily transfused patients with lower risk myelodysplastic syndrome (MDS)

A study published in the Leukaemia Research journal has concluded that iron chelation therapy (ICT) appears to improve survival in heavily transfused lower risk myelodysplastic syndromes (MDS) patients, and that adequate ICT was found significantly to improve overall survival in an independent manner.

In the multicentre study, 97 lower-risk (IPSS low and int-1 risk groups) regularly transfused MDS patients who received red blood transfusions, enrolled over a one-month period, were followed for 2.5 years. Data — on medical history, serum ferritin level at diagnosis and during follow up, and chelation therapy type (desferrioxamine deferasirox or deferiprone), tolerance, date of onset and termination, reasons for discontinuation, compliance, and impact on transfusion dependence and haematological characteristics — were collected and underwent multivariate analysis.

The team found that median survival for chelated patients was 10.3 years, compared with 4.4 years for non-chelated patients. This was a significant (p<0.0003) difference, more than doubling the overall survival in ICT-treated patients.

The positive effect of ICT on overall survival in other chronic anaemias, such as thalassemia major, is already established, though its benefits on MDS had previously only been suggested in small retrospective studies. However, current UK guidelines already recommend ICT in this patient population to avoid the possible toxic effects of iron overload (including damage to the heart, liver and endocrine system and death) caused by the repeated blood transfusions that are common among MDS patients. 

10th May 2010

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Hanover Communications

Healthcare is evolving rapidly. To stand out from the crowd requires a potent combination of rich insight, innovative ideas and...

Latest intelligence

What challenges still face clinical trial recruitment and retention?
Discover the reasons for the current clinical trial recruitment challenges facing pharma and the life sciences industry, and how the search for solutions to the problem continues...
“Fake News” and Credibility in Medical Publishing
Natalie Yeadon from Impetus Digital shares her thoughts on fighting fake news in Pharma and healthcare....
Delivering true value: what does it mean for KAM in cancer care?
Lisa Alderson, Business Development Director at Wilmington Healthcare, explores the challenges that pharma’s KAM teams face in engaging with the NHS and how they must evolve...

Infographics