Please login to the form below

Not currently logged in
Email:
Password:

Kite bags $90m upfront in two Asian deals for lead CAR-T drug

Partners with Daiichi Sankyo and Fosun Pharma to focus in on non-Hodgkin lymphoma

Kite PharmaKite Pharma has forged cancer immunotherapy alliances in Japan and China as it expands its business into Asian markets.

In China, Kite has formed a joint venture with Chinese drugmaker Fosun Pharma to develop lead chimeric antigen receptor T cell (CAR-T) therapy axicabtagene ciloleucel (also known as KTE-C19), which has been submitted for approval in the US via a rolling marketing application.

That deal nets the US biotech $40m in upfront payments, plus $20m of funding to support clinical development and manufacturing and $35m in regulatory and commercial milestones, and Kite will own 50% of the new company.

The Shanghai-based JV has also taken an option to develop two other candidates - KITE-718, a MAGE A3/A6-directed therapy for solid tumours, and KITE-439, which targets human papillomavirus type 16 E7 oncoprotein. Opt-in and milestone payments for these two candidates could reach $140m.

Kite's Japanese partnership is with Daiichi Sankyo and will see Kite receive $50m upfront and $200m in development and commercial milestone payments in return for rights to axicabtagene ciloleucel. Daiichi Sankyo is also taking an option to license KITE-718 plus "certain other product candidates that proceed to a US investigational new drug application filing over the next three years".

Kite has submitted axicabtagene ciloleucel as a treatment for patients with refractory aggressive non-Hodgkin lymphoma (NHL) in the US, and is vying with Novartis to be the first company to win marketing approval anywhere in the world for a CAR-T therapy.

The therapy involves harvesting patient's T cells and engineering them to express a chimeric antigen receptor (CAR) that targets CD19, an antigen expressed on the cell surface of B-cell lymphomas and leukaemias, which redirects the T cells to kill cancer cells.

The two new deals could unlock a sizeable new patient population for axicabtagene ciloleucel - there are approximately 73,000 newly-diagnosed cases of NHL in China each year, while Japan has around 9,300 new cases.

Article by
Phil Taylor

11th January 2017

From: Sales

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Pegasus

At Pegasus, we specialise in helping deliver healthy messages through integrated communication programmes. In fact, inspiring healthy decisions is all...

Latest intelligence

Bowel Cancer Awareness Month
Synergy Vision are supporting Bowel Cancer Awareness Month. Bowel cancer is one of most common cancers diagnosed in the UK, but with early diagnosis and treatment, most cases can be...
Anthill_icon_Green_18_Dialogue.png
The right way to capture customer data
Digital communication should be a two-way process with information flowing backwards and forwards between you and healthcare professionals. That digital technology enables HCPs to give feedback is a big part...
Anthill_icon_Green_17_Multi-channel.png
Can you access your own content?
The rapid development of multichannel communication opens new opportunities to provide high-value experiences for healthcare professionals and gives you more places than ever to tell your product story. But unless...

Infographics