Please login to the form below

Not currently logged in
Email:
Password:

Lundbeck Alzheimer's drug effective in phase II trial

New method of action could offer benefits over current treatments

A phase II study of Lundbeck's candidate Alzheimer's treatment Lu AE58054 has found that it improves cognition when added to a standard drug for the disease, and the company now intends to press ahead with a pivotal trials programme.

Lu AE58054 is a selective serotonin 5HT6 receptor antagonist, with a different mechanism of action than currently available Alzheimer's medications such as Pfizer/Eisai's Aricept (donepezil), Novartis' Exelon (rivastigmine) and Shire's Reminyl (galantamine), which work by inhibiting the action of cholinesterases.

Current Alzheimer's drugs are acknowledged to have useful but limited benefits in treating patients with the disease, so any drug that could improve their efficacy could have a significant impact.

The phase II trial of Lu AE58054 in 278 patients with mild-to-moderate Alzheimer's disease looked at the effects of adding the drug to treatment with a standard dose of donepezil. It found a statistically significant improvement in cognition over 24 weeks when compared to donepezil plus placebo.

Secondary endpoints, including measures of global status and activities of daily living also showed positive trends with the addition of Lu AE58054.

Investigational drugs to treat Alzheimer's must generally show an impact on both cognition and activities of daily living to meet the requirements for regulatory approval.

Lu AE58054 was also well-tolerated in combination with donepezil at the selected dose, said Lundbeck, which will present the data in full later this year at upcoming medical congresses.

The company said Alzheimer's disease affects over 26m people worldwide, with a cost to society estimated at $600bn per year. Lu AE58054 is also being developed to treat cognitive impairments associated with schizophrenia.

Other 5-HT6 receptor antagonists in development as cognition enhancers include GlaxoSmithKline's SB-74257 (phase II), Abbott's ABT-354 (phase II), Pfizer's PF-5212377 (phase II) and Roche/BioTie's SYN-120 (phase I ).

29th May 2012

Share

Related Hub content

    Your search did not contain any words. Please try again.

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Health4Brands

At H4B, we are an energetic new team with fresh ideas, but we have over 275 years of combined experience...

Latest intelligence

Online Physician Communities
Is the pharma industry bad?
Surveys of doctors and the public suggest not...
Salary survey now open - how will you measure up?
Take part for a chance to win a Kindle Fire HD tablet...
Online Physician Communities
M3 and partners win Digital Sales Aid Award
Wins for campaign to overcome limited doctor engagement with pharma-owned websites...