Please login to the form below

Not currently logged in
Email:
Password:

Lundbeck Alzheimer's drug effective in phase II trial

New method of action could offer benefits over current treatments

A phase II study of Lundbeck's candidate Alzheimer's treatment Lu AE58054 has found that it improves cognition when added to a standard drug for the disease, and the company now intends to press ahead with a pivotal trials programme.

Lu AE58054 is a selective serotonin 5HT6 receptor antagonist, with a different mechanism of action than currently available Alzheimer's medications such as Pfizer/Eisai's Aricept (donepezil), Novartis' Exelon (rivastigmine) and Shire's Reminyl (galantamine), which work by inhibiting the action of cholinesterases.

Current Alzheimer's drugs are acknowledged to have useful but limited benefits in treating patients with the disease, so any drug that could improve their efficacy could have a significant impact.

The phase II trial of Lu AE58054 in 278 patients with mild-to-moderate Alzheimer's disease looked at the effects of adding the drug to treatment with a standard dose of donepezil. It found a statistically significant improvement in cognition over 24 weeks when compared to donepezil plus placebo.

Secondary endpoints, including measures of global status and activities of daily living also showed positive trends with the addition of Lu AE58054.

Investigational drugs to treat Alzheimer's must generally show an impact on both cognition and activities of daily living to meet the requirements for regulatory approval.

Lu AE58054 was also well-tolerated in combination with donepezil at the selected dose, said Lundbeck, which will present the data in full later this year at upcoming medical congresses.

The company said Alzheimer's disease affects over 26m people worldwide, with a cost to society estimated at $600bn per year. Lu AE58054 is also being developed to treat cognitive impairments associated with schizophrenia.

Other 5-HT6 receptor antagonists in development as cognition enhancers include GlaxoSmithKline's SB-74257 (phase II), Abbott's ABT-354 (phase II), Pfizer's PF-5212377 (phase II) and Roche/BioTie's SYN-120 (phase I ).

29th May 2012

Share

Related Hub content

    Your search did not contain any words. Please try again.

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
CSafe Global

CSafe Global is the only global provider of a full line of cold chain solutions and is the world’s largest...

Latest intelligence

Free White Paper: Customer Experience for Pharma
To learn why an effective customer experience strategy is vital for pharma, download our white paper “Customer experience for pharma” to learn more....
How ethical is your brand plan? Introducing the hEQ.
Assess your brand plan’s Healthcare Ethics Quotient and see how these questions can give your brand plan a new perspective and engage your internal teams and external customers....
solution_options.png
Why e-detailing must give options to healthcare professionals
We know, we know. You want to talk about your treatment right away, but this really is an essential step that will make your e-detailing even more credible....