Please login to the form below

Not currently logged in

Nexavar shows promise in thyroid cancer

Potential new indication for Bayer/Onyx drug

Bayer Nexavar sorafenib 

Bayer and Onyx Pharmaceuticals look set to add another indication to the labelling of their oncology drug Nexavar after revealing positive data in a phase III trial in the treatment of thyroid cancer.

Nexavar (sorafenib) improved progression-free survival (PFS) in the DECISION trial, which included patients with differentiated thyroid cancer that would not respond to treatment with radioactive iodine.

Bayer said that it intends to file the data to regulatory agencies to seek approval for Nexavar in these patients, adding to its current approvals in liver and kidney cancer.

The companies are also investigating the drug in a number of other cancers, but suffered a setback last year when Nexavar failed to improve overall survival in patients with advanced non-small-cell lung cancer (NSCLC).

Thyroid cancer is one of the few malignancies that is increasing in incidence  and is the sixth most common cancer in women, with about three times as many women as men diagnosed, said the pharma company.

There are more than 160,000 new cases of thyroid cancer and approximately 25,000 people die of the disease worldwide each year.

Like many oncology therapies Nexavar has grown slowly but steadily since its launch in 2006 and racked up an impressive 11.5 per cent increase to €580m ($755m) in the first nine months of 2012.

Latterly much of its growth has come from emerging markets – notably China where use reportedly doubled in liver cancer in 2012 compared to 2011 – and the brand would benefit from new indications to help maintain momentum in established pharma markets.

Bayer and Onyx are also carrying out phase III studies of Nexavar in breast cancer, adjuvant treatment of liver and kidney cancer, with other indications such as colorectal and ovarian cancer following in phase II.

4th January 2013

From: Research



Featured jobs

Subscribe to our email news alerts


Add my company
Lucid Group Communications Limited

We are industry-leading thinkers when it comes to education. We use the latest academic thinking on the psychology of behaviour...

Latest intelligence

Is the pharma business model ready for precision medicine?
Precision medicine promises to revolutionise patient outcomes and reduce costs for industry but is pharma ready for it? Blue Latitude Health co-founder Head of Strategy Fred Bassett explores the challenges...
The NHS and ABPI at 70: inching closer to the triple win
The NHS and UK pharma’s ABPI both turn 70 this year. After years of transactional relationships, there’s a will to work more closely - but friction on prices and value...
What pharma marketers can learn from behavioural science
Pharma behavioural science and traditional emotional marketing create a powerful mix of techniques that have impact on real lives....