Please login to the form below

Not currently logged in
Email:
Password:

NICE rejects aggressive breast cancer drug

NICE has rejected GSK's Tyverb in combination with capecitabine for the treatment of an aggressive form of advanced breast cancer

The UK's National Institute for Health and Clinical Excellence (NICE) has issued its Appraisal Consultation Document (ACD) rejecting GlaxoSmithKline's (GSK) oral Tyverb (lapatinib) in combination with capecitabine for the treatment of an aggressive form of advanced breast cancer (ErbB2-positive).

The decision follows the July 2009 request of NICE's appeal panel that the appraisal committee should reconsider lapatinib under the Institute's end of life (EOL) supplementary guidance.

The EOL guidance was specifically developed to help small numbers of patients, who have only a few months to live, gain access to important new medicines. GSK submitted additional data demonstrating that lapatinib met all three of the EOL criteria. 

Though NICE recognised this, it felt lapatinib was still not a cost-effective use of NHS resources. This decision was made despite GSK offering the Tyverb Patient Access Programme, which allows National Health Service (NHS) patients in the UK free access to lapatinib for the first three months of treatment.   

Simon Jose, general manager, GSK UK, commented: "NICE developed additional criteria specifically to help secure greater patient access to new treatments that offer precious extra time at the end of life. It is disappointing that, despite acknowledging Tyverb meets these criteria and GSK offering to bear the cost of lapatinib for up to 12 weeks, NICE is still proposing to reject lapatinib. We will continue to offer our patient access programme to individual NHS Trusts to ensure patients have access to Tyverb."

Twenty-six Trusts have enrolled in the patient access programme to date. 

21st October 2009

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Real Science Communications

Real Science Communications is a scientific centre of excellence, infusing credibility and scientific rigour into the conversations around health and...

Latest intelligence

50 questions for delivering an exceptional healthcare brand experience
Our 50-question brand planning checklist for healthcare ensures you deliver an exceptional experience, based on what your stakeholders want and need...
The brand strategy revolution
Introducing a new tool for developing a stakeholder-centric brand, based on the experience your patients and their HCPs want and need....
How Medisafe is using AI to improve patient adherence
Dina Patel speaks to Omri Shor, Co-Founder and CEO of Medisafe, to find out how his medication management app is tackling the problem of poor adherence....

Infographics