Please login to the form below

Not currently logged in
Email:
Password:

Novartis signs $500m immuno-oncology deal

Gains access to Xoma's TGFb antibody programme
Novartis

Novartis has licensed an immuno-oncology programme from Xoma in a deal that could be worth more than $500m.

The deal covers rights to Xoma's anti-transforming growth factor-beta (TGFb) antibody programme.

Under the terms of the agreement, the Berkeley-based Xoma will receive $37m in upfront payments and is also eligible to receive up to $480m if all development, regulatory and commercial milestones are met.

John Varian, CEO of Xoma, said: “XOMA and Novartis have worked closely together for several years to develop new product candidates.

“When they expressed interest in our anti-TGFb programme, we knew Novartis was the best company to bring this exciting potential therapy to the patients whom it may help.”

TGFb is an immune suppressive cytokine involved in a number of cellular processes, including inhibition of cell growth and immune suppression. Elevated levels of cell growth can be behind numerous diseases, including cancer and fibrosis.

According to Xoma, three isoforms of TGFb exist in humans: TGFb1, 2 and 3. TGFb1 is overexpressed in many cancers and is thought to increase the chances of metastasis.

Its lead candidate Xoma089 is a fully human, high-affinity, late preclinical monoclonal antibody that neutralises TGFb1 and 2 while sparing TGFb3.

Xoma is currently at the forefront in the discovery and development of therapeutic antibodies. The company, however, was left devastated when its Servier-partnered drug for Behcet's disease failed a phase III study in July.

Share prices after this failure fell by 80% - but after the agreement with Novartis they have now risen by 32%.

Article by
Nikhil Patel

5th October 2015

From: Sales

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
emotive.

emotive. is an award-winning healthcare communications agency working with leading global and EMEA companies in life sciences including medical device...

Latest intelligence

PM Society Digital Awards – the power of together
Our chief executive, Emma Statham, writes about the value of awards and the power of together....
Seduction_feature_image_thumb.jpg
Seduce anyone in four simple steps
You know the health of the global economy is dependent on our ability to seduce one another – don’t you? And you know that we need to be able to...
What Would Jeremy Do? : Assessing the impact of a Corbyn-led Labour government
GK Strategy are delighted to announce the launch our latest briefing paper entitled ‘What Would Jeremy Do? Assessing the impact of a Corbyn-led Labour government’....

Infographics