Please login to the form below

Not currently logged in
Email:
Password:

Novo Nordisk files another Lantus rival in Japan

Danish pharma company's combination product - known as DegludecPlus in Europe – submitted to regulators

Novo Nordisk has filed for approval of its combination product based on insulin degludec and insulin aspart in Japan as it continues its assault on the ultra-long-acting insulin market.

The combination product - referred to as DegludecPlus in Europe - is part of a franchise that Novo Nordisk is positioning to challenge the dominance of Sanofi's Lantus (insulin glargine) in the diabetes category. Lantus brought in sales of€3.92bn ($5.2bn) last year and is the world's top-selling insulin product.

The combination product combines insulin degludec - a new ultra-long-acting insulin analogue that is currently under regulatory review in Europe, the US and Japan - with Novo Nordisk's fast-acting NovoRapid product, which had revenues of 12.8 billion krone ($2.3bn) last year.

One of the advantages of insulin degludec is that it can be administered at any time of day to fit in with the needs of the patient, and that flexibility has led to speculation that in time it could overtake Lantus and become the top insulin product worldwide with multibillion dollar sales.

Novo Nordisk launched another long-acting insulin called Levemir a few years ago but this has not been able to match Lantus' growth trajectory.

The Japanese marketing application is based on results of the BOOST clinical programme, which involved nearly 3,000 type 1 and type 2 diabetes patients and showed improved blood glucose control compared to Lantus, as well as reductions in the rate of hypoglycaemia episode during the night compared to biphasic insulin aspart.

Novo Nordisk is planning to develop a series of combination products based on insulin degludec. Last year, it started phase III trials of a combination product based on insulin degludec and GLP-1 analogue liraglutide - the active ingredient in its Victoza product.

The pharma company is claiming to be further ahead with this programme than a Sanofi follow-up to Lantus which combines insulin glargine with GLP-1 analogue lixisenatide, which will be marketed as Lyxumia if it is approved.

9th March 2012

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
EY Life Sciences

Our global reach Against a backdrop of regulatory, digital, financial and global transformation, Life Sciences companies are finding integration and...

Latest intelligence

BrAInPME.png
The future of medical content: The personal touch
The purpose of delivering personalised content to HCPs is not just about customer experience, it's about improving healthcare. Our Commercial Director, Tib Catania discusses what ‘deep learning’ means for the...
Rise of the patient expert - an interview with Michael Seres
Founded by Michael Seres in 2011, 11 Health is a connected medical device company currently working to change the lives of patients using stoma bags. Content Marketing Manager Liz Inskip...
Making sense of Nutraceuticals in China
Published in eyeforpharma February 2017 by Marc Yates...

Infographics