Please login to the form below

Not currently logged in
Email:
Password:

Novo Nordisk files another Lantus rival in Japan

Danish pharma company's combination product - known as DegludecPlus in Europe – submitted to regulators

Novo Nordisk has filed for approval of its combination product based on insulin degludec and insulin aspart in Japan as it continues its assault on the ultra-long-acting insulin market.

The combination product - referred to as DegludecPlus in Europe - is part of a franchise that Novo Nordisk is positioning to challenge the dominance of Sanofi's Lantus (insulin glargine) in the diabetes category. Lantus brought in sales of€3.92bn ($5.2bn) last year and is the world's top-selling insulin product.

The combination product combines insulin degludec - a new ultra-long-acting insulin analogue that is currently under regulatory review in Europe, the US and Japan - with Novo Nordisk's fast-acting NovoRapid product, which had revenues of 12.8 billion krone ($2.3bn) last year.

One of the advantages of insulin degludec is that it can be administered at any time of day to fit in with the needs of the patient, and that flexibility has led to speculation that in time it could overtake Lantus and become the top insulin product worldwide with multibillion dollar sales.

Novo Nordisk launched another long-acting insulin called Levemir a few years ago but this has not been able to match Lantus' growth trajectory.

The Japanese marketing application is based on results of the BOOST clinical programme, which involved nearly 3,000 type 1 and type 2 diabetes patients and showed improved blood glucose control compared to Lantus, as well as reductions in the rate of hypoglycaemia episode during the night compared to biphasic insulin aspart.

Novo Nordisk is planning to develop a series of combination products based on insulin degludec. Last year, it started phase III trials of a combination product based on insulin degludec and GLP-1 analogue liraglutide - the active ingredient in its Victoza product.

The pharma company is claiming to be further ahead with this programme than a Sanofi follow-up to Lantus which combines insulin glargine with GLP-1 analogue lixisenatide, which will be marketed as Lyxumia if it is approved.

9th March 2012

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Digitas Health

Digitas Health is the only digital-at-the-core brand agency designed to connect today's healthcare brands with today's healthcare consumers and professionals....

Latest intelligence

Healthy narratives?
In medical market research we see that most physicians are not early adopters, preferring to wait for their colleagues to adopt new medicines and practices before doing so themselves. There...
Allergies – Always a story
Saycomms looks into the seasonal trend of allergies stories in the media and the communication campaigns launched in UK in 2015....
When is sun safety doing more harm than good?
Say Communications analyses the impact of sun safety campaigns in the news and on consumers...

Infographics