Please login to the form below

Not currently logged in
Email:
Password:

Pfizer dealt another blow as Torisel fails kidney cancer trial

Results are another setback in company's bid to extend the indications for its mTOR inhibitor

Pfizer's bid to cement the position of its mTOR inhibitor Torisel in the kidney cancer market suffered a setback when the drug failed to show a benefit in a phase III combination study.

Torisel (temsirolimus) was being tested alongside Roche's Avastin (bevacizumab) to see if it was more effective than Avastin plus interferon alfa-2b in treating patients with advanced renal cell carcinoma (RCC).

Pfizer's drug failed to achieve the primary endpoint of extending progression-free survival (PFS) in the INTORACT study, which sought to expand Torisel's indications from its current approval as a first-line monotherapy in advanced RCC patients with poor prognostic risk.

The news is another setback in Pfizer's bid to extend the indications for the mTOR inhibitor. In May a late-stage trial of the drug in the second-line treatment of RCC found that Torisel was not as effective as rival drug Nexavar (sorafenib) from Bayer in improving survival.

"This trial advances our knowledge about the role and limitations of combining targeted therapies in the treatment of advanced RCC," commented Dr Mace Rothenberg, Pfizer's senior vice president of clinical development and medical affairs, oncology. 

"Additional analyses will be performed to help us understand this result," he added.

RCC has been a fertile development ground for pharma companies in recent years, and Pfizer has built up its own portfolio of treatments for the cancer, which occurs in around 270,000 people around the world each year.

In addition to Torisel, the pharma company won approval for kinase inhibitor Inlyta (axitinib) as a second-line treatment for RCC earlier this year, joining its Sutent (sunitinib) product for the cancer which debuted in 2006.

The failure of its latest study closes the door on a potentially lucrative line extension for Torisel, as Avastin plus interferon alfa-2b is a widely used first-line therapy in advanced RCC patients.

13th August 2012

From: Research

Share

Tags

In association with:

Resources


Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Reynolds-MacKenzie

Reynolds-MacKenzie is the multi award-winning specialist public relations practice within OPEN Health; the first ever agency in the health communications...

Latest intelligence

Designing Human Experiences
Applying science to the creative process to improve lives...
Assured Global Delivery at The Right Temperature®
CSafe Global partners with DHL Global Forwarding to assure pharmaceutical manufacturer successful temperature sensitive delivery to South America....
The changing regulatory environment
Code of practice changes are encouraging transparency in pharma/HCP relationships...