Please login to the form below

Not currently logged in
Email:
Password:

Pfizer’s arthritis drug Enbrel widens its European licence

Gains new indication for early-stage inflammatory joint disease

PfizerPfizer's blockbuster arthritis drug Enbrel (etanercept) has won a new indication in Europe to treat early-stage inflammatory joint disease.

The European Commission gave the green-light to a label extension for Enbrel in the treatment of adult patients with severe non-radiographic axial spondyloarthritis (nr-axSpA).  

The third best-selling drug in the world last year, Enbrel's latest indication puts the drug on a par with its rival TNF-inhibitors Humira and Cimzia and gives it a slight advantage over Remicade.

axSpA is a painful and progressive type of arthritis that affects the hip and lower spine joints and patients with the non-radiographic form are still in the early stage of the disease - experiencing symptoms before structural changes can be detected by x-ray.  

axSpA is estimated to affect between 0.3 and 1 per cent of the adults and up to 12 per cent of patients with the chronic lifelong inflammatory disease nr-axSpA will progress to the more serious ankylosing sponylitis within two years.     

Dr Berkeley Phillips, Pfizer UK's medical director, said “This licence extension reflects Pfizer's continuing commitment to enhancing the scientific community's understanding of rheumatic diseases and providing treatment options for patients to address an unmet need in this less well-understood but equally painful form of spondyloarthritis.”  

The European Commission's approval decision was based on data from Study 1031, which showed 32.4 per cent of Enbrel patients showed significant improvements compared to 15.7 per cent of those receiving a placebo. Treatment related adverse events were reported in 57 per cent and 45 per cent of patients in the etanercept and placebo groups, respectively.  

The EC approval is for the treatment of adults with severe non-radiographic axSpA with objective signs of inflammation as indicated by elevated CRP and/or MRI evidence, who have had an inadequate response to non-steroidal anti-inflammatory drugs (NSAIDs).

Article by
Dominic Tyer

6th August 2014

From: Sales

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
BASTARD . LONDON

BASTARD . LONDON collaborates with you to amplify brand ideas into a visual brand language that resonates and engages with...

Latest intelligence

Empowered patients: shaking the foundations of healthcare
Precision medicine represents a new paradigm in healthcare.This new approach to treating and preventing disease views the patient holistically, analysing their genes, environment and lifestyle, and using this information to...
A uniquely English genomic medicine service
The UK National Health Service is developing one standardised approach to embedding precision medicine across the whole of England. Blue Latitude Health speaks to Dr Tom Fowler, Deputy Chief Scientist...
Blended Intelligence
Data is the most valued commodity of the modern world. For P&P it's all about the application....

Infographics