Please login to the form below

Not currently logged in
Email:
Password:

R&D news in brief

Our weekly round up of R&D news in brief

Tracleer fails to impress in lung disease trials

Expectations that Actelion's drug Tracleer could double its sales potential have been dashed following disappointing clinical trials for treatment in lung disease. The drug was tested in two forms of pulmonary fibrosis to see if it could help patients' ability to walk for six minutes but failed to show any benefit. ìThe data is obviously disappointing and reduces the possibility of diversifying the product portfolio away from its reliance on Tracleer in pulmonary arterial hypertension (PAH),î said analyst Hernani deFaria at ZKB. Tracleer is currently approved for treatment of PAH, a rare type of hypertension, and is expected to bring in revenues of about $470m this year.

Cellcept shows promise

Immune-suppression drug CellCept works better than the standard chemotherapy medication in treating kidney complications from lupus, according to a new study. Nearly a quarter of patients who took the new drug saw their kidney problems go into remission after six months, compared with just 6 per cent of those receiving the older treatment. Lupus is a crippling and sometimes life-threatening diseases that mostly strikes women of childbearing age. CellCept is made by Hoffmann-La Roche ad is approved by the US Food and Drug Administration to prevent organ rejection in transplant patients.

GSK to work on AIDS vaccine

GSK is planning to develop an experimental AIDS vaccine by fusing genes from the immunodeficiency virus onto an existing vaccine for measles. GSK Biologicals will license the measles-vaccine vector technology from Institut Pasteur of France and researchers from both groups will jointly develop the vaccine. While scientists believe a vaccine to defeat the virus is possible, so far it has proved difficult to develop an effective one. The GSK research will be supported by a public-private collaboration, and the initial project has been boosted by a grant of Ä5.5m from the European Union.

Obesity impacts on jab effectiveness

Injecting drugs into the buttocks may not be as reliable a method as first though, according to new research. Doctors from a Dublin hospital found that fleshy tissue on buttocks could sometimes prevent jabs properly penetrating to the muscle. ìThere is no question that obesity is the underlying cause,î said lead researcher Dr Victoria Chan, based at the Adelaide and Meath Hospital. ìWe have identified a new problem related, in part, to the increasing amount of fat in patients' buttocks.î Intramuscular injections are currently a common alternative when patients cannot take pills.

30th September 2008

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
3 Monkeys Zeno

3 Monkeys Zeno is an award winning global creative communications consultancy – home to a collective of creative and strategic...

Latest intelligence

Patients are ready to embrace decentralised clinical trials, are you?
Traditional clinical trial designs simply can’t withstand the impact of COVID-19. While before the pandemic, some in clinical research were beginning to adopt virtual components, the move towards designing hybrid...
Has the pandemic opened up a future of accelerated diagnosis and better care for rare disease patients?
The challenge with rare disease is in the name – it's rare, so awareness is limited and diagnosis hindered. Could a more virtual existence change this? A Medical Affairs viewpoint...
The other side of … blood cancer
To stay motivated for the fight, some patients need to feel like active players in the treatment journey, not passengers to every decision....

Infographics