Please login to the form below

Not currently logged in
Email:
Password:

Roche’s Avastin strikes out again with NICE

Pharma company fails to justify drug's cost in advanced breast cancer

Roche's Avastin

Roche's Avastin

Roche's Avastin has added advanced breast cancer to its growing list of unsuccessful appraisals by the UK's National Institute for Health and Clinical Excellence (NICE).

The health technology assessment body ruled that Avastin (bevacizumab) does not provide enough patient benefit to justify its cost and has not recommended its use by the NHS in England.

In publishing its guidance NICE noted its consistently negative stance on Avastin in this indication had not met any objections from either Roche or other consultees at any stage of the appraisal process.

Andrew Dillon, NICE chief executive, said: “We can't recommend a drug that has not been shown to work as well as, or better than, current treatments and costs much more.

“Evidence presented to the independent Appraisal Committee did not conclusively show that bevacizumab, in combination with capecitabine, could improve overall survival or improve a patient's quality of life more than current treatment.

“These uncertainties combined with the high cost of bevacizumab mean the drug simply isn't cost-effective.”

Avastin (bevacizumab) was appraised, in combination with Roche's chemotherapy drug Xeloda (capecitabine), as a first-line treatment of metastatic breast cancer in people for whom treatment with other chemotherapy options, including taxanes or anthracyclines, are not appropriate.

The average monthly cost of using Avastin in this setting comes to around £3,690. In earlier guidance NICE's appraisal committee said the most plausible Incremental Cost Effectiveness Ratio (ICER) for Avastin was more than £82,000 per QALY gained.

The drug's role in breast cancer was brought into question last year though, after studies suggested that the risks associated with the drug outweighed its benefits in advanced breast cancer.

In the US, the FDA stripped Avastin of its approval in that indication last November, while in 2010 the EMA restricted its use to only include combination with paclitaxel. Later, the EU agency said treatment alongside Xeloda was also an option.

Although the drug was the most requested under the English Cancer Drugs Fund, NICE has consistently refused to recommend its use in any setting. The Institute's negative guidance has previously included Avastin for use in combination with a taxane for the first-line treatment of metastatic breast cancer, as well as for first-line treatment of advanced colorectal cancer.

22nd August 2012

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Cadient EU

Cadient takes a HUMAN FORWARD approach to transforming the digital experience. We believe digital transformation is driven by elegantly crafted...

Latest intelligence

BrAInPME.png
The future of medical content: The personal touch
The purpose of delivering personalised content to HCPs is not just about customer experience, it's about improving healthcare. Our Commercial Director, Tib Catania discusses what ‘deep learning’ means for the...
Rise of the patient expert - an interview with Michael Seres
Founded by Michael Seres in 2011, 11 Health is a connected medical device company currently working to change the lives of patients using stoma bags. Content Marketing Manager Liz Inskip...
Making sense of Nutraceuticals in China
Published in eyeforpharma February 2017 by Marc Yates...

Infographics