Please login to the form below

Not currently logged in
Email:
Password:

Sanofi reveals successful Lyxumia studies

Sanofi reports successful phase III trial results for diabetes treatment Lyxumia

Sanofi's investigational product Lyxumia (lixisenatide) has achieved its primary efficacy endpoint of significantly reducing HbA1c for patients with type 2 diabetes without significantly increasing their risk of hypoglycaemia, when used as an add-on therapy to basal insulin (in association with or without metformin).

GetGoal-L is one of nine studies in the GetGoal phase III clinical programme, and the second trial to investigate the benefits of lixisenatide 20µg once-daily combined with basal insulin. It was a randomised (double-blind), placebo-controlled study with a 24-week main treatment period, and a total of 495 patients received either lixisenatide or placebo.

GetGoal-L showed a significant reduction in HbA1c levels with lixisenatide, without a significant increase in the incidence of symptomatic hypoglycaemia versus placebo. In addition, patients treated with lixisenatide had significantly improved postprandial plasma glucose after a test meal. Patients in the lixisenatide arm of the study also reported a significant reduction in body weight.

Professor A H Barnett, professor of medicine and clinical director at Heartlands Hospital, Birmingham, UK, said: "These results are encouraging and highlight the potential value of adding lixisenatide to basal insulin to improve glycaemic control. They are another important milestone in the GetGoal clinical trial programme and the findings from the programme so far suggest that lixisenatide has the potential to be an important new therapy for patients with type 2 diabetes."

The results confirm those reported on GetGoal-L Asia, this time in a broader population including both Caucasian and Asian patients. As expected with a GLP-1, the most commonly reported adverse side effect with lixisenatide was nausea with a low rate of discontinuation.

6th June 2011

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
An agency called Owen

We’re a Healthcare Communications Agency specialising in Multi-channel Marketing to make you Digitally Fitter, Stronger & Faster....

Latest intelligence

DEMAND DIVERSITY REPORT 02: Why is the LGBTQ+ community facing poorer health outcomes due to COVID-19?
We’re all aware that clinical trials have been discussed more widely since the COVID-19 pandemic. While that’s a great thing for raising awareness of clinical trials in general, it’s also...
CHECKLIST 04: Let’s make your patient recruitment strategies a success
From how to generate insights to define your audience to drilling down those all-important key messages, our checklist has everything you need to think of, covered....
Multichannel engagement and the need for greater understanding of European markets
By Laurence Olding and Georgina James...

Infographics