Please login to the form below

Not currently logged in
Email:
Password:

Study clears Pfizer’s Champix of serious risks

Smoking-cessation drug 'does not increase risk' of depression or heart attacks
Pfizer building

New research indicates Pfizer's stop-smoking drug Champix may not increase the risk of depression and heart attacks as previously thought.

The study, published in The Lancet Respiratory Medicine, followed over 160,000 patients for five years who received nicotine replacement therapy (NRT), GlaxoSmithKline's anti-smoking drug Zyban (bupropion) or Pfizer's Champix (varenicline).

The researchers found that people taking either Champix or Zyban were no more likely to suffer a heart attack or develop depressive symptoms than those on NRT.

Additionally, use of Champix was associated with a significantly reduced risk of ischaemic heart disease, cerebral infarction, heart failure, arrhythmia and depression.

Aziz Sheikh, one of the study's researchers and co-director of the University of Edinburgh's Centre for Medical Informatics, said: “On the basis of our extensive analysis, we believe it is highly unlikely that varenicline has any significant adverse effects on cardiac or mental health.

“Regulators such as the Food and Drug Administration (FDA) should review their safety warning in relation to Champix as this may be unnecessarily limiting access to this effecting smoking cessation aid.”

The results come as good news for Pfizer, which is already undertaking a very similar study evaluating neuropsychiatric safety, the results for which will be available later this year.

Champix, marketed as Chantix in the US, achieved global sales of $647m in 2014 making it one of the highest-selling smoking cessation drugs.

However, since the controversy surrounding the drug's side effects, sales have fallen from 2007, when it brought in $883m.

Since 2008, the drug has been at the centre of nearly 3,000 lawsuits, however, all the cases were settled by Pfizer in June 2013.

Article by
Nikhil Patel

9th September 2015

From: Research

Share

Tags

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
Real Science Communications

Real Science Communications is a scientific centre of excellence, infusing credibility and scientific rigour into the conversations around health and...

Latest intelligence

World Pancreatic Cancer Day 2018: Combating misconceptions in pancreatic cancer
Patients diagnosed with pancreatic cancer face a dismal prognosis, with the disease having the lowest survival rate of all major cancers. In spite of this, pancreatic cancer research is chronically...
World Diabetes Day: Interaction and impact of diabetes on mental health
For World Diabetes Day on the 14th November 2018, Nisha Shahrukh - Medical Writer at Mednet Group has written an article depicting the impact diabetes has on mental health. Including...
EU
Innovation in merger control and the impact on the pharmaceutical sector
Is focusing on pipeline products enough to assess regulatory risks?...

Infographics