Please login to the form below

Not currently logged in

Tagrisso tops rival drugs on survival in first-line lung cancer

Takes fight to Pfizer's Vizimpro


AstraZeneca has the improvement in overall survival (OS) it needed for lung cancer therapy Tagrisso (osimertinib), as it tries to double down on its use in the first-line setting.

Updated results from the FLAURA trial show that Tagrisso extends survival in previously-untreated patients with EGFR-positive non-small cell lung cancer (NSCLC), building on 2017 results showing that the drug could extend progression-free survival (PFS).

The improvement in OS came over other drugs in the EGFR inhibitor class, namely AZ’s own Iressa (gefitinib) and Roche’s Tarceva (erlotinib), and according to AZ’s head of oncology José Baselga it is the only medicine to achieve this outcome.


AZ’s head of oncology José Baselga

“Tagrisso provides an unprecedented survival outcome versus previous standard-of-care [EGFR] inhibitors” in first-line EGFR-mutated NSCLC, he said, and that means it should be the new standard therapy for this indication.

Tagrisso had previously shown a trend towards improvement in OS in FLAURA, but earlier readouts were too immature to show a statistically-significant benefit.

Now, the new data should help AZ continue to build momentum with Tagrisso at a time when the EGFR inhibitor category is becoming increasingly competitive, with new entrants such as Pfizer’s Vizimpro (dacomitinib) jostling for market share.

It will also help the company make its case to payers. For example, AZ is in the midst of an appeal against a decision by UK cost-effectiveness body NICE to turn down Tagrisso in first-line EGFR-positive NSCLC treatment, in part because the OS data was inconclusive compared to the older, cheaper rivals.

NICE also judged that the drug would not eligible for inclusion in the Cancer Drugs Fund, saying it was too expensive, while at the same time it recommended Pfizer’s Vizimpro for routine NHS use in this indication.

Tagrisso is already dominating the second-line EGFR-positive NSCLC market and AZ has been working hard to push the new drug into the first-line setting, with what seems to be some success in many markets.

In its first-half results, AZ reported that sales of Tagrisso, now comfortably its top-selling drug, almost doubled to $1.4bn, with the growth spurred by first-line use in the US, Europe and Japan and second-line use in China. AZ thinks the drug could reach $3bn this year on current growth rates.

Article by
Phil Taylor

9th August 2019

From: Research



COVID-19 Updates and Daily News

Featured jobs


Add my company
Blue Latitude Health

Blue Latitude Health is a creative marketing consultancy. Founded in 2003, our combination of heritage, approach and capability gives us...

Latest intelligence

DEMAND DIVERSITY REPORT 02: Why is the LGBTQ+ community facing poorer health outcomes due to COVID-19?
We’re all aware that clinical trials have been discussed more widely since the COVID-19 pandemic. While that’s a great thing for raising awareness of clinical trials in general, it’s also...
CHECKLIST 04: Let’s make your patient recruitment strategies a success
From how to generate insights to define your audience to drilling down those all-important key messages, our checklist has everything you need to think of, covered....
Multichannel engagement and the need for greater understanding of European markets
By Laurence Olding and Georgina James...