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Takeda's diabetes drug enters phase III

Takeda Pharmaceutical's TAK-875, a novel investigational therapy for diabetes, has entered phase III development

Takeda Pharmaceutical's TAK-875, a novel investigational therapy for diabetes, has entered phase III development.

TAK-875 is being investigated for its ability as an agonist of GPR40, a receptor in pancreatic islet cells, with Takeda hoping it can selectively improve glucose-dependent insulin secretion with a potential for reduced risk of hypoglycaemia.

It is the first such drug to reach the phase III stage of development.

Dr Thomas Strack, vice president, clinical science, Takeda Global Research & Development Center, US, said: "Takeda is committed to enhancing the clinical investigation of TAK-875 in order to accelerate the development of a potential new type 2 diabetes treatment option for patients and healthcare professionals."

The first phase III trial in the US/Europe programme will enrol about 450 patients with type 2 diabetes who are not adequately controlled on diet and exercise. The study's primary endpoint will be the change in blood glucose levels at week 24.

19th October 2011

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