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Teva begins second Phase III trial of oral MS treatment

Teva and Active Biotech have announced that patients are being enrolled for a global, double-blind phase III study of laquinimod for the treatment of multiple sclerosis
Teva and Active Biotech have announced that patients are being enrolled for a global, double-blind phase III study of laquinimod for the treatment of multiple sclerosis (MS).

The trial, known as BRAVO, aims to enrol 1,200 patients with relapsing-remitting multiple sclerosis (RRMS). It will evaluate the safety, tolerability and effectiveness of laquinimod and produce risk-benefit data for laquinimod versus Avonex, an injectable treatment.

The BRAVO trial will run alongside the ongoing ALLEGRO trial, a similar global, double-blind study involving around 1,000 patients.

"All currently approved multiple sclerosis (MS) treatments are administered via injection or infusion. The ability to provide a safe and effective oral treatment option would be a significant advancement for the treatment of MS," said Dr Timothy Vollmer medical director at the Rocky Mountain MS Center in Colorado, and principal investigator of the BRAVO study.

Results of a phase IIb study published in The Lancet, show that the orally-administrated drug significantly reduced magnetic resonance imaging (MRI) in RRMS patients by an average of 60 per cent.

Laquiniod, developed by Swedish company, Active Biotech, was licensed to Teva in 2004. Teva reports that laquiniod has demonstrated potential effectiveness in the treatment of other autoimmune diseases. The company expects to begin development of laquinimod for Crohn's disease and lupus nephritis in the near future.

16th July 2008

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