Please login to the form below

Not currently logged in
Email:
Password:

Teva says Copaxone repairs tissue damage in MS

Study data gives boost to company’s biggest-selling product over competition

Teva has reported the results of a new study which indicates that its multiple sclerosis drug Copaxone can repair some of the tissue damage seen in brains of MS patients.

The study used magnetic resonance imaging (MRI) techniques to track the effects of Copaxone (glatiramer acetate) in 40 patients with relapsing/remitting MS over a 12-month period. The subjects had not previously been treated with Copaxone.

The results indicate that treatment with Copaxone significantly increased the magnetisation transfer ratio (MTR) in the patients, which is an emerging MRI technique used to investigate abnormalities in brain structures.

"Increased values indicate potential remyelination and axonal tissue repair," said Teva in a statement.

Remyelination - the restoration of the myelin sheath surrounding neurons which degenerates in MS – often occurs spontaneously in the brains of patients afflicted with MS.

However, sometimes the process fails, resulting in the death of the nerve fibre (axon), making remyelination a major therapy target.

The data - which is published in the journal Frontiers in Bioscience, also reinforced the positive impact of Copaxone in reducing MS-related lesions in the brains of the test subjects.

At enrolment, all patients had one or more contrast-enhancing lesions (CELS) for a total of 115 CELS. After 12 months, the number of CELs decreased to 21.

The new findings are a boost for Copaxone, which has been a major driver of growth at Teva for years, but is facing competitive pressure from newer MS treatments, including Novartis' orally-active rival Gilenya (fingolimod)

Generic competition is also a threat for Teva.

The company recently trimmed back its 2011 and 2012 revenue forecasts, in part because of expected pressure on Copaxone growth, which remains its biggest-selling product with third-quarter 2011 sales in excess of $1bn.

4th January 2012

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Aptus Health

Aptus Health is dedicated to advancing health engagement. The company offers end-to-end digital health engagement solutions spanning all areas of...

Latest intelligence

Patient-centricity in improving patient recruitment advertising
This blog looks into the importance of concepts and patient centricity in patient recruitment....
AI and life sciences
AI: the smart money is on the smart thinking
Looking at the three key areas where AI is being applied: drug discovery, clinical decision-making and clinical trials...
Virtual Engagement At Porterhouse: Reflections on the past few months
A look at how the pitfalls of virtual engagement can be avoided and the key advantages of virtual client and KOL engagement strategies in a now predominantly digital world....

Infographics