Please login to the form below

Not currently logged in
Email:
Password:

Transition halts diabetes drug development

Transition Therapeutics has discontinued development of a new therapy for type 2 diabetes after it failed to meet efficacy endpoints

Transition Therapeutics has discontinued development of a potential new therapy for type 2 diabetes after it failed to meet the efficacy endpoints in a late-stage clinical study. The drug, gastrin analogue TT-223, was being tested in combination with a GLP-1 analogue that Transition licensed from Lilly.

"While TT-223 has shown efficacy through development, these results indicate that it does not have the product profile for a diabetes therapy," the company said.

The randomised, double-blind study enroled 150 patients who received either a placebo regimen or daily doses of TT-223 in combination with weekly doses of GLP-1 analogue for four weeks. The study also included a five-month follow-up period.

Transition said its broad in-licensing and collaboration agreement with Lilly will not be affected by the termination of the TT-223 development programme. The deal, which was announced in March of this year, gives Transition exclusive worldwide rights to a series of Lilly's pre-clinical drug candidates for diabetes and related co-morbid conditions. Lilly retains the option to re-acquire the rights to the compounds later in their development.

The Lilly drugs represent a new class of compounds that, in pre-clinical diabetes models, showed potential to provide glycaemic control and weight loss.

The deal signed this year built on a pre-existing partnership between the two companies in the area of gastrin-based therapies for diabetes developed by Transition. That collaboration, which was formed in 2008, granted Lilly exclusive worldwide rights to develop and commercialise Transition's gastrin based therapies, including TT-223.

Toronto-based Transition does not yet have any marketed products. Its lead product in development is a phase III drug for Alzheimer's disease.

21st September 2010

Share

Featured jobs

Subscribe to our email news alerts

PMHub

Add my company
PharmiWeb Solutions

PharmiWeb Solutions creates, delivers and manages digital solutions for the pharmaceutical and healthcare segment. From digital marketing, to patient education...

Latest intelligence

ema1
The European Medicines Agency: PRIME’d for access?
Leela Barham examines the impact of the EMA's PRIME fast track system after two years...
How can pharma engage with key stakeholders on NHS service transformation?
Steve How, Paul Midgley and Oli Hudson, of the Wilmington Healthcare consulting team, explain how pharma should make its case for change...
michael elliot
The race for an HIV ‘cure’
Supercharging therapies as pharma and patients work together...

Infographics