Please login to the form below

Alzheimer's: the numbers we cannot forget

In this article, Consultant David Cooney explores the success rate of trials in AD and the reasons for this incredulous situation, as well as looking at the some of the glimmers of light at the end of the tunnel.
Normally in our blogs and articles at Blue Latitude Health we offer up snapshots of things we have learned from our experience working in a therapy area. I would love to be talking about our latest thinking around launching new therapies in Alzheimer’s disease (AD) but I can’t – no one can. This is because in the last 13 years, only one new drug has been approved for patients with AD. The most recently approved drug was in 2014, bringing the total number of agents approved across AD to 5.

In this article, I’m going to explore the success rate of trials in AD and the reasons for this incredulous situation, as well as look at the some of the glimmers of light at the end of the tunnel.

Among the worst attrition rates in the industry

99.6% of all trials in Alzheimer’s disease (AD) between 2002 and 2012 failed. This is one of the highest clinical trial failure rates in healthcare. During this period, 413 trials were performed using 95 compounds with 8 unique modes of action (MOAs). 35.1% of these studies were with disease modifying agents, 36.6% were symptomatic agents aimed at improving cognition, while 18% were disease modifying immunotherapies. Failures in these trials have been associated with lack of efficacy, excessive side effects, or challenges in trial execution; leaving patients and HCPs with 5 therapies to choose from:



These therapies have shown significant, but clinically marginal, benefits in relation to cognition, daily function, and behaviour. Patients on these therapies remain stable for approximately a year or more, with a slower subsequent rate of decline to untreated patients.

So what is the problem? Has there been sufficient investment from industry? Why haven’t we optimised the activity of proven active agents for better results? Why haven’t we identified more potent targets in the disease pathology with all the recent developments in genetics

Has pharma been investing in Alzheimer ’s disease?

They have - 78% of all trials in AD from 2002 to 2012 were funded by the pharmaceutical industry. If we consider that the mean duration of a phase 3 trial in AD is 90.9 weeks, with an average of 833 patients, and a 0.04% likelihood of success - the cost of AD trials and the amount of investment that has been made with little to no return is shocking. When you consider the success rate of a new oncology therapy is 19%, any company continuing to invest in this area deserves credit because the unmet need in AD is hard to fathom. The number of deaths in AD per year is on par with cancer, and the annual cost of care actually exceeds that of cancer - which is surprising considering there is 10x more research funding in cancer than AD. This is an area in dire need of innovation, and with significant reward for whoever can make that breakthrough given the market valuation at $6.5billion


Download the full article from Blue Latitude Health

19th July 2016

Share

Tags

Company Details

Blue Latitude Health

+44 203 328 1840

Contact Website

Address:
Blue Latitude Health (UK)
140 Aldersgate Street
London
EC1A 4HY
United Kingdom

Latest content on this profile

Q&A with Dr Timothy Vollmer, leading MS Neurologist
Blue Latitude Health sits down with key opinion leader and specialist neurologist Dr Timothy Vollmer to better understand the paradigm shift in MS treatment. He explains the challenges neurologists face when making treatment decisions, and why patients need to be treated with more efficacious drugs earlier on.
Blue Latitude Health
Living my best life with multiple sclerosis
Multi-award-winning advocate and patient engagement champion Trishna Bharadia gives a valuable insight into life with multiple sclerosis. She explains how treatment has changed, how our healthcare systems and pharma can unite to improve quality of life for MS patients today, and why her diagnosis isn’t stopping her achieving her goals.
Blue Latitude Health
Creative review: ESMO 2018
BLH reviews the creative concepts exhibited at the European Society for Medical Oncology (ESMO) 2018 Congress, crowning our best booth winners and giving key insights on how to develop an inspiring design for your booth.
Blue Latitude Health
A unique tool for turning data into brand strategy
Head of Insight Martine Leroy, uses her 25+ years’ experience to develop an exclusive perceptual framework for research design and analysis, which generates a deeper understanding of customer needs and the changing market dynamics
Blue Latitude Health
Positive disruption: getting to the bottom of big data
BLH speaks to Nicole Huyghe, founder and Managing Director of data science consultancy Boobook, about the growing need from businesses for data-driven decision making.
Blue Latitude Health
We've moved!
Blue Latitude Health has moved office to a new location in Barbican, Central London, following a year of substantial growth.
Blue Latitude Health