Focus on multiple myeloma treatment: Witnessing a transformation
Consultant David Cooney of Blue Latitude Health will take you through how that transformation has happened, and where the treatment of multiple myeloma is heading.
I get very excited by science,
specifically pharmacology, and when I was studying drug development I used to
read case studies about the impact ground-breaking drugs had, and imagine what
it must have been like to be part of that success. I used to harass an old mentor
of mine who was involved in the Herceptin launch for stories about introducing
such an innovative treatment, hoping one day I’d get a chance to be part of such
a transformation in care.
I'm
now part of a team at Blue Latitude Health working in multiple myeloma (MM),
and with each publication that emerges, it’s clear that we are witnessing a
transformation in the treatment of multiple myeloma. In this article, I will
take you through how that transformation has happened, and where the treatment
of multiple myeloma is heading.
The Therapeutic Index of
multiple myeloma therapies
“It is easy to be overwhelmed by hype in cancer
research, with promising new discoveries often portrayed as so-called game
changers….but myelomais a rare exception” [sic]was the opening of a recent editorial in the Lancet on
multiple myeloma. To appreciate the context of this statement we need to
consider what treatment options were like for myeloma patients in the past.
If
we reflect on what the treatment options were 10 years ago, two drugs stand out
– melphalan and thalidomide. Melphalan, a
distant cousin of the mustard gas used to kill World War I soldiers, and thalidomide, the infamous chiral drug which caused birth
defects in the 1960s. These drugs have been shown to be efficacious options for
patients with MM, but with a low therapeutic index. This meant
significant cost in terms of toxicity, and marginal impact on the overall
survival of patients.
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