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BACE1 inhibitor

This page shows the latest BACE1 inhibitor news and features for those working in and with pharma, biotech and healthcare.

Eisai to tackle dementia in new US research facility

Eisai to tackle dementia in new US research facility

The area could very well be a gamble for the Japanese group as rivals AstraZeneca and Eli Lilly - who partnered up to look into BACE1 inhibitor candidates in Alzheimer’s - dropped ... Merck &Co has also seen failure with its BACE1 inhibitor verubecestat

Latest news

  • Off BACE: AZ/Lilly drop Alzheimer’s drug lanabecestat Off BACE: AZ/Lilly drop Alzheimer’s drug lanabecestat

    The demise of the BACE1 inhibitor – also known as AZD3293/LY3314814 – adds to the litany of failures among drugs intended to treat Alzheimer’s, and specifically those trying to slow down ... A few weeks ago, Merck &Co abandoned its BACE1 inhibitor

  • Another Alzheimer's bust as Merck & Co stops verubecestat study Another Alzheimer's bust as Merck & Co stops verubecestat study

    Late-stage BACE1 failure could be an ominous signal for Eli Lilly/AZ and Biogen/Eisai. ... Merck &Co has abandoned the phase III trial of its BACE1 inhibitor verubecestat in Alzheimer’s in what could be an ominous signal for Eli Lilly/AstraZeneca and

  • Alzheimer's disease pipeline takes multiple hits Alzheimer's disease pipeline takes multiple hits

    MK 8931 (Merck &Co.) is a potential first-in-class, potent Aß precursor protein cleaving enzyme (BACE1) inhibitor. ... LY 2886721 (Lilly) is another BACE1 inhibitor that was in phase I/II development in the US, Japan and some EU countries, but the phase

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  • Interview: Mike Hutton, Lilly Interview: Mike Hutton, Lilly

    Lilly has not been immune from such difficulties. Its BACE1 inhibitor LY 2886721 and amyloid-beta treatment semagacestat also failed, the latter in a large phase III clinical trial.

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China’s clinical trial shake-up
As many of the obstacles to running clinical trials in China fall away, the country is proving to be a better research location...
Alzheimer’s disease – is Europe prepared if a breakthrough treatment becomes available?
Healthcare leaders in the European Union should begin preparing for a breakthrough now...
The UK’s new five-year pricing agreement
Pharma has agreed to capped growth again - in exchange for uptake promises...

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