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CAR-T therapy

This page shows the latest CAR-T therapy news and features for those working in and with pharma, biotech and healthcare.

Celgene boosts CAR-T stake again with Bluebird Bio deal

Celgene boosts CAR-T stake again with Bluebird Bio deal

Mere weeks after completing its acquisition of CAR-T specialist Juno, Celgene has added to its cell therapy pipeline with another clinical-stage CAR-T candidate from Bluebird Bio. ... It could also receive additional, undisclosed milestones if the CAR-T

Latest news

  • Novartis gets speedy reviews for new Kymriah filings Novartis gets speedy reviews for new Kymriah filings

    Novartis’plans to expand the use of its CAR-T therapy Kymriah look rosier after the FDA and EMA both said they would carry out speedy reviews of new indications. ... CAR-T is a new approach to immuno-oncology that uses modified versions of a patient's

  • Spark’s Luxturna becomes US’s first approved gene therapy Spark’s Luxturna becomes US’s first approved gene therapy

    two CAR-T therapies for blood cancers which involve genetically modifying cells outside the body. ... Novartis’first-approved CAR-T therapy Kymriah (tisagenleucel) has been priced at $475, 000 per course in the US, but a recent Bloomberg report

  • Gilead adds to CAR-T assets with Cell Design Labs buyout Gilead adds to CAR-T assets with Cell Design Labs buyout

    One CDL approach - called synNotch - is designed to require two antigens rather than one to active the CAR-T cell, potentially making the therapy more tumour-specific. ... The acquisition was announced just before the American Society of Haematology (ASH)

  • Novartis files CAR-T therapy CTL109 in Europe Novartis files CAR-T therapy CTL109 in Europe

    Novartis files CAR-T therapy CTL109 in Europe. Analysts predict Kymriah could become a $1bn-plus product in Europe. ... Fresh from the first regulatory approval for its CAR-T therapy CTL019 in the US, Novartis has now turned its attention to Europe.

  • Novartis moves swiftly with lymphoma filing for CAR-T Kymriah Novartis moves swiftly with lymphoma filing for CAR-T Kymriah

    Novartis moves swiftly with lymphoma filing for CAR-T Kymriah. Will go up against Kite Pharma's Yescarta if approved. ... Just a few weeks after claiming the first approval for a CAR-T therapy, Novartis is trying to extend its lead by filing for a second

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Latest Intelligence

  • No incentive for a cure No incentive for a cure

    These include Kymriah, the pioneering CAR-T cell therapy from Novartis, which demonstrated a remarkable 83% remission rate in children and young adults with B-cell precursor acute lymphoblastic leukaemia. ... One of the biggest questions with a curative

  • Can value-based healthcare take off and reach for the skies? Can value-based healthcare take off and reach for the skies?

    CAR-T cell therapy for children with B-cell ALL. ... costs. It was then backed with a ‘no response-no payment’contract. It has also struck novel reimbursement packages with its heart failure therapy Entresto and its psoriasis treatment Cosentyx.

  • The rise of real-world evidence The rise of real-world evidence

    Novartis secured such an outcome-based model for its CAR-T therapy Kymriah. ... Spark Therapeutics has a similar arrangement for its gene therapy. These agreements make real-world efficacy a requirement for full payment for a drug.

  • Deal Watch January 2018

    Having terminated the development of its lead CAR-T therapy, JCAR015, early last year after several patient deaths in a phase II clinical trial in relapsed/refractory B-cell acute lymphoblastic ... Juno Therapeutics/ Celgene. CAR-T and TCR therapeutics

  • The gold standard of scientific evidence The gold standard of scientific evidence

    Additionally, RWE is being used to inform. creative drug pricing. When seeking coverage for Kymriah, a new CAR-T therapy, Novartis has an agreement with the Centers for Medicaid and Medicare

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  • Celgene boosts CAR-T stake again with Bluebird Bio deal Celgene boosts CAR-T stake again with Bluebird Bio deal

    Mere weeks after completing its acquisition of CAR-T specialist Juno, Celgene has added to its cell therapy pipeline with another clinical-stage CAR-T candidate from Bluebird Bio. ... It could also receive additional, undisclosed milestones if the CAR-T

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