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CAR-Ts

This page shows the latest CAR-Ts news and features for those working in and with pharma, biotech and healthcare.

CAR-Ts take centre stage as ASH18 comes to a close

CAR-Ts take centre stage as ASH18 comes to a close

to administer therapy that doesn’t require the process of harvesting, modifying and re-infusing cells needed with autologous CAR-Ts. ... what some commentators think is a reason (alongside price and reimbursement) for sluggish uptake of

Latest news

  • Amgen’s BCMA drug on course to challenge CAR-Ts in myeloma Amgen’s BCMA drug on course to challenge CAR-Ts in myeloma

    There were signs of efficacy with AMG 420 even at a lower dose of 200µg/day, but the big question now is whether off-the-shelf drugs will match CAR-Ts ... treated in trials of Bluebird’s CAR-Ts had seven or more, with a might higher proportion of the

  • ASH18: CAR-T and drugs give new options for multiple myeloma ASH18: CAR-T and drugs give new options for multiple myeloma

    earlier timepoint, and Celgene is due to report results on no fewer than three anti-BCMA CAR-Ts developed by Juno – namely JCARH125, MCARH171 and FCARH143. ... five complete responses in five patients – that could pose a threat to the BCMA-targeting

  • Regeneron’s early stage bispecific shows promise Regeneron’s early stage bispecific shows promise

    Bispecifics and antibody drug conjugates will challenge CAR-Ts. The potentially revolutionary nature of CAR-Ts has made them the hottest properties in haemato-oncology in recent years, but a wave ... This approach could see them match the clinical

  • Celgene to launch five new products through to 2020 Celgene to launch five new products through to 2020

    myelofibrosis, thalassaemia therapy luspatercept, and CAR-T candidates lisocabtagene maraleucel (liso-cel) for lymphoma and bb2121 for multiple myeloma. ... The two CAR-Ts could be approved in 2020, while the other three candidates are due to be

  • Allogene raises $324m from record-breaking IPO for off-the shelf CAR-Ts Allogene raises $324m from record-breaking IPO for off-the shelf CAR-Ts

    Arie Belldegrun (left) and David Cheng . Belldegrun and Cheng they can go one better than these first generation autologous CAR-Ts. ... Allogene is among a number of companies who want to leapfrog the leaders with allogenic or 'off the shelf' CAR-Ts.

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