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diffuse large B-cell lymphoma

This page shows the latest diffuse large B-cell lymphoma news and features for those working in and with pharma, biotech and healthcare.

Gilead swoops on Forty Seven with $4.9bn all-cash deal

Studies have also suggested that blocking CD47 can send some tumour cells into programmed cell death (apoptosis). ... Forty Seven is also testing the drug in patients with non-Hodgkin's lymphoma, diffuse large B-cell lymphoma and three solid tumours –

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IMV preps pivotal trials for ovarian cancer T cell therapy

The therapy is being tested alongside Merck &Co’s PD-1 inhibitor Keytruda (pembrolizumab) in two phase 2 studies, including an investigator-led trial in patients with advanced-stage diffuse large ... B-cell lymphoma (DLBCL) and another spanning
FDA starts priority review of Kite’s CAR-T for mantle cell lymphoma

Despite recent advances, patients with relapsed/refractory mantle cell lymphoma currently face a significant lack of effective treatment options once their disease no longer responds to currently available therapy,” said Ken ... Gilead/Kite’s
EMA begins review of Kite’s CAR-T for mantle cell lymphoma

Kite is seeking approval for the CAR-T therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) – according to the company, if KTE-X19 is ... Gilead/Kite already have one approved CAR-T therapy in the arsenal
EU grants conditional approval to Roche's lymphoma drug Polivy

The EU approval clears Polivy for use in combination with chemotherapy drug bendamustine and anti-CD20 rituximab in adults with relapsed/refractory diffuse large B-cell lymphoma (DLBCL) who are ineligible ... Filings for approval in first-line DLBCL
Incyte signs lymphoma deal worth up to $1.1bn with MorphoSys

tafasitamab. . MorphoSys licensed tafasitimab from Xencor in 2010, and has been studying the anti-CD19 antibody in B-cell malignancies in a number of ongoing clinical trials. ... This includes trials of tafasitamab in non-Hodgkins lymphoma, chronic

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European biotech: a new generation of leaders emerges

The phase 2 L-MIND study in diffuse large B-cell lymphoma (DLBCL) showed the combination of tafasitamab with Celgene’s Revlimid (lenalidomide) had an overall response rate of 60%, with ... Nevertheless, European biotech has reason to be optimistic
25 Women Leaders in UK Healthcare (part 2)

13. SORAYA BEKKALI. Gene therapy pioneer. Cell and gene therapy is definitely the most exciting development in biopharma research, promising breakthroughs and even cures for previously untreatable diseases. ... It has brought to market not one but two
Cancer immunotherapy: What's on the horizon?

antigen receptor T-cell (CAR-T) therapies from Novartis and Gilead gained regulatory approval in 2017 for acute lymphoblastic leukaemia (ALL) and diffuse large B-cell lymphoma (DLBCL) after showing remarkable ... Celgene and Juno hope to crash the party
Deal Watch January 2018

pivotal trial for relapsed and/or refractory diffuse large B-cell lymphoma (DLBCL). According to Celgene's press release, regulatory approval for JCAR017 in the US is anticipated in 2019 with ... DLBCL = diffuse large B-cell lymphoma. BTK = Bruton's
Pharma deals in April 2015

MEDI4736 is an immune checkpoint inhibitor which is targeted against programmed cell death (PD-L1). ... its SAR3419, an antibody-drug conjugate designed to treat diffuse large B-cell lymphoma (DLBCL) and other blood cancers.

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Highlights in haematologic malignancy from ASH 2018

refractory diffuse large B-cell lymphoma. ... Other abstracts reported on CAR T-cell therapies for multiple myeloma directed against the B-cell maturation antigen (BCMA).

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