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mantle cell lymphoma

This page shows the latest mantle cell lymphoma news and features for those working in and with pharma, biotech and healthcare.

AZ’s BTK inhibitor Calquence fails in COVID-19 study

Calquence is approved to treat a number of blood cancers and is indicated for use in adults with previously treated mantle cell lymphoma (MCL) as well as adults with chronic lymphocytic ... leukaemia (CLL) or small lymphocytic lymphoma (SLL).

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Merck strengthens oncology pipeline with $2.75bn VelosBio deal

resulted in objective clinical responses in 47% of patients with mantle cell lymphoma (MCL) and 80% of patients with diffuse large B-cell lymphoma (DLBCL). ... Pioneering work by VelosBio scientists has yielded VLS-101, which in early studies has
FDA starts priority review of Kite’s CAR-T for mantle cell lymphoma

X19 in relapsed or refractory mantle cell lymphoma. ... Despite recent advances, patients with relapsed/refractory mantle cell lymphoma currently face a significant lack of effective treatment options once their disease no longer responds to currently
EMA begins review of Kite’s CAR-T for mantle cell lymphoma

Kite is seeking approval for the CAR-T therapy for the treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) – according to the company, if KTE-X19 is ... Relapse rates in mantle cell lymphoma remain overwhelmingly high and
BeiGene’s Brukinsa misses the mark in head-to-head Imbruvica trial

Failed to beat rival in rare white blood cell cancer. BeiGene’s BTK inhibitor Brukinsa was unable to beat rival Imbruvica from Johnson &Johnson/AbbVie in Waldenstrom’s macroglublinemia. . ... Brukinsa is BeiGene’s first drug to have been approved
Merck buys ArQule for $2.7bn in another cancer bolt-on deal

clinical activity in non-Hodgkin’s lymphoma (NHL) and an impressive three out of six responders in an aggressive form of NHL called Richter’s transformation. ... also in early-stage testing and had phase 1 results on show at ASH in CLL and mantle

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Encouraging signs in biomarker R&D

Similarly, high TMB is correlated with better response to immune checkpoint inhibitors, so is the presence of TIL or a T cell GEP. ... mantle cell lymphoma minimal as an example.
AstraZeneca: building a new ‘open innovation’ pharma company

AstraZeneca launched five significant new medicines in 2017: immunotherapy Iminzi, Calquence for mantle cell lymphoma, Qtern in type 2 diabetes, Bevespi Aerosphere in COPD and Fasenra for severe asthma.

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Mistrust in medical research: a patient perspective: The recent development of several COVID-19 vaccines has placed medical research firmly in the spotlight, highlighting public confusion and misinformation about clinical trials. Patient advocate, Trishna Bharadia reveals what the...
Real-world evidence: breaking boundaries in rare disease: Generating data for drug launches is a challenging process. In rare diseases, with small patient populations and high unmet need, evidence generation is even more complex. Consultant Sarah Poole and...
The heavy toll of COVID-19 on cancer patients: We all know that finding and treating cancer early saves lives. During the COVID-19 pandemic, oncology treatments paused while cancer continued to spread. So, what has been the impact of...