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RNA interference

This page shows the latest RNA interference news and features for those working in and with pharma, biotech and healthcare.

NICE says no to rival Alnylam and Akcea amyliodsis drugs – but deal could be done

NICE says no to rival Alnylam and Akcea amyliodsis drugs – but deal could be done

Gaining NICE recommendation would be a major milestone for both companies – Onpattro is Alnylam’s debut product from its RNA interference (RNAi) drug platform, while Tegsedi is similarly Akcea’s first ... product from its antisense drug technology,

Latest news

  • Moderna files record $500m IPO for RNA pipeline Moderna files record $500m IPO for RNA pipeline

    Could be the largest IPO for a biotech start-up. Moderna Therapeutics, a specialist in messenger RNA-based drugs, has filed a $500m initial public offering (IPO) that would break all ... It’s a different spin on other RNA approaches, such as RNA

  • Alnylam gets EU nod for Onpattro amid pricing backlash Alnylam gets EU nod for Onpattro amid pricing backlash

    The  EMA has cleared Onpattro (patisiran) – the first RNA interference drug approved in the EU – for adult hATTR amyloidosis patients with stage 1 or 2 nerve damage (polyneuropathy), one of the

  • ICER says Alnylam’s Onpattro should cost 90%-95% less ICER says Alnylam’s Onpattro should cost 90%-95% less

    In draft guidance, the Institute for Clinical and Economic Review (ICER) says that RNA interference drug Onpattro (patisiran) – and Akcea/Ionis’ antisense candidate Tegsedi (inotersen) which is due for an FDA

  • Alnylam claims RNAi milestone with Onpattro approval Alnylam claims RNAi milestone with Onpattro approval

    After years of ups and downs, triumph for gene-silencing tech. Alnylam’s faith in the gene-silencing potential of RNA interference (RNAi) drugs has finally paid off, with the US ... RNAi drugs are used to block gene expression, binding to the messenger

  • Alnylam’s amyloidosis drug heads latest crop of CHMP approvals Alnylam’s amyloidosis drug heads latest crop of CHMP approvals

    The green light sets up the first product approval for Alnylam, an RNA interference specialist which has been working on gene-silencing drugs for around 15 years and is also due ... RNA process that results in TTR protein expression.

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Latest appointments

  • Silence appoints chief medical officer Silence appoints chief medical officer

    These studies involve Silence's investigational portfolio of RNA interference (RNAi) therapeutics, which aim to treat conditions by selectively turning off genes expressed in an individual with a certain disease.

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