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Threshold

This page shows the latest Threshold news and features for those working in and with pharma, biotech and healthcare.

Roche’s Tecentriq misses survival mark in frontline NSCLC

Roche’s Tecentriq misses survival mark in frontline NSCLC

endpoint. Roche’s PD-L1 inhibitor Tecentriq (pemetrexed) was unable to meet the threshold for a significant improvement in overall survival (OS) when added to Eli Lilly’s Alimta (pemetrexed) and

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  • Viking throws downn gauntlet in NASH battle Viking throws downn gauntlet in NASH battle

    MGL-3196 hitting the 30% reduction threshold.

  • FDA rejects GSK’s Nucala for COPD FDA rejects GSK’s Nucala for COPD

    In the METREX trial reported last year Nucala hit its objective of reducing moderate to severe exacerbations, cutting them by 18% compared to placebo, which scraped over the statistical significance threshold.

  • FDA rejects GSK’s Nucala for COPD FDA rejects GSK’s Nucala for COPD

    In the METREX trial reported last year Nucala hit its objective of reducing moderate to severe exacerbations, cutting them by 18% compared to placebo, which scraped over the statistical significance threshold.

  • ICER says Alnylam’s Onpattro should cost 90%-95% less ICER says Alnylam’s Onpattro should cost 90%-95% less

    ICER says Alnylam’ s Onpattro should cost 90%-95% less. Even after discounts the medication exceeds the cost-effectiveness threshold. ... Nevertheless, Alnylam’s price for Onpattro of $450, 000 per patient per year “even taking into account

  • Spark sputters on haemophilia A gene therapy safety scare Spark sputters on haemophilia A gene therapy safety scare

    meeting the factor threshold because of reactions – suggesting that could affect SPK-8011’s competitive profile compared to other haemophilia A gene therapies from the likes of BioMarin Pharma, Pfizer/Sangamo ... Meanwhile, Spark says it has data

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