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trial failure

This page shows the latest trial failure news and features for those working in and with pharma, biotech and healthcare.

Pfizer’s plans for Inlyta go awry with failed adjuvant trial

The failure of ATLAS means Pfizer now has a lot more riding on its JAVELIN trial of Inlyta in combination with Merck KGaA-partnered PD-L1 inhibitor Bavencio (avelumab) in ... JAVELIN remains on track, but the failure of the adjuvant trial also knocks

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Incyte/Merck trial failure bodes ill for IDO class

Incyte/Merck trial failure bodes ill for IDO class. The much-touted cancer immunotherapy combination fails to show improvement over Keytruda alone. ... Incyte wasn’t attempting to downplay the implication of the trial in a conference call on Friday,
Celixir cleared to start trial of stem cell therapy for heart failure

Celixir cleared to start trial of stem cell therapy for heart failure. ... The initial Heartcel trial results are very exciting, showing the first evidence in humans of disease reversal, scar reduction and heart regeneration.
Shire separates out neuroscience as it considers its future

The company also faces outside pressures, and shortly before Christmas was mentioned in the press as a possible big pharma takeover target after the failure of a pivotal trial for its
Bayer drug-device combo for pneumonia flunks phase III test

Shares in Nektar were down a little over 6% in after-hours trading after news of the trial failure broke during the Thanksgiving holiday.
Regeneron drops RSV drug

infection. The trial enrolled 1, 149 infants who were randomised to treatment with either two doses of suptavumab delivered eight weeks apart, or a matched placebo. ... A vaccine candidate - Novavax' RSV-F - missed the mark in a phase III trial last year

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VIDEO interview: Neil Weir, UCB

Avoiding failure. By taking this approach to research, it's possible to avoid one of the major pitfalls facing pharma today – the high cost of late-stage trial failure. “ ... Particularly when we have high failure rates in late stages in clinical
Customer valuation in pharma

Multiple studies have pegged the probability of clinical trial success at between 13-20 per cent. ... This estimate has remained constant over decades. Among the major reasons for clinical trial failure are problems that rest squarely in the domain of

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Alzheimer's: the numbers we cannot forget

This is one of the highest clinical trial failure rates in healthcare. ... Failures in these trials have been associated with lack of efficacy, excessive side effects, or challenges in trial execution; leaving patients and HCPs with 5 therapies to choose
A forward march for adaptive designs

For example, poor dose selection in phase II is frequently cited as one of the top causes of late-stage clinical trial failure. ... As such, it has prioritised phase II/III adaptive trial designs as well as other types of study.

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