Best Use of Data Visualisation

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Finalist

Big Data for in Silico R&D: Visualizing label expansion opportunities

by Oxford PharmaGenesis

Summary of work

Manual identification of potential new indications for licensed medicines is challenging, time-consuming and expensive. In response to this, following multiple workshops with our client, we built the IN-SIGHT virtual R&D platform, an in silico drug discovery tool that integrates over 20 data sources, leveraging artificial intelligence (AI) to derive meaningful analytics efficiently. IN-SIGHT allows our client to scope new label extension opportunities for existing products, identify portfolio gaps and assess the competitive landscape. IN-SIGHT has the potential to transform the way existing drug product portfolios are assessed.
One component of the platform, IO-MAP (Interactive Overlapping Mechanisms of Action Plot), integrates multiple data sets in a novel interactive data visualization. More than a visualization, the tool allows users to interrogate the underlying database and, based on overlapping drug mechanisms of action, surface potential repurposing opportunities and explore the underlying evidence for a specific drug or a mechanism of action in the potential new indication. In this way, IO-MAP is able to uncover hidden opportunities and provides a unique drug differentiation method, allowing a global panel of experts to screen potential new indications rapidly and effectively.

To date, the program has successfully generated and leveraged data through newly established channels and partnerships with engaged stakeholders. The program has already successfully influenced clinical practice and policy at global, country and clinic levels via novel insights and targeted, patient-focused solutions. Adherence is gaining the attention it has long needed, and real-world outcomes will improve as a result.

Judges’ comments

This entry demonstrated clear purpose, goals and approach that delivered an innovative AI-based tech solution and a tangible product. An impressive entry and a really interesting idea - well constructed and impactful.