Please login to the form below

Not currently logged in

Annovis Bio’s lead therapeutic shows ‘significant improvements’ in Alzheimer’s, Parkinson’s

Patients from a small phase 2a study saw their ADAS-Cog11 scores improve by 4.4 points

Biotech company Annovis Bio has revealed positive results for its lead investigational therapeutic ANVS401 in Alzheimer’s disease (AD) and Parkinson’s disease (PD).

The results come from a small phase 2a study evaluating ANVS401 in 14 AD patients and 14 PD patients.

The results show that patients treated with ANVS401 for 25 days achieved statistically significant cognitive improvement, measured by the Alzheimer’s Disease Assessment Scale-Cognitive Subscale 11 (ADAS-Cog11).

Specifically, patients in the ANVS401-treated group saw their ADAS-Cog11 scores improve by 4.4 points from baseline until 25 days – an improvement of 30%.

The ANVS401 treatment group also showed an improvement of 3.3 points (22%) compared to placebo at 25 days.

Biogen’s aducanumab, in comparison, showed a 1.4 point improvement in ADAS-Cog13 over 18 months, while a phase 2 study of Cassava’s simufilam demonstrated a 1.6 point improvement on ADAS-Cog11 after six months.

“The results from the first cohort of 14 AD and 14 PD patients show that the drug is effective in both diseases. Seeing efficacy in both patient populations supports our hypothesis that the impairment of axonal transport, the information highway of the nerve cell, affects nerve cells in the same way in both diseases,” said Maria Maccecchini, chief executive officer of Annovis Bio.

“The toxic cascade in neurodegeneration begins with high levels of neurotoxic proteins, which impair axonal transport, increase inflammation and eventually lead to nerve cell death and permanent loss of cognition and function,” she added.

ANVS401 is designed to inhibit the translation of multiple neurotoxic proteins – high levels of neurotoxic proteins result in impaired axonal transport, which plays a key role in the communication between and within nerve cells.

Through this inhibition, ANVS401 can improve axonal transport, reduce inflammation, protects nerve cell death and improve cognition and function, Annovis said in a statement.

Annovis is continuing to analyse the cerebral spine fluid and plasma samples of the first 28 patients from the phase 2a study, with the aim of measuring the reversal of the toxic cascade.

Additional data is expected to be revealed in the next two months, the company added, with full study data anticipated in July or August 2021.

When the phase 2a study is completed, Annovis said it will request a meeting with the US Food and Drug Administration (FDA) to present the results, along with its chronic toxicology study in animals.

Article by
Lucy Parsons

24th May 2021

From: Research



COVID-19 Updates and Daily News

Featured jobs


Add my company
certain health

Transforming the way health brands and companies communicate, we deliver creative science led, insight-driven solutions that give award winning results...

Latest intelligence

The power of communication: Engaging diverse groups in healthcare
Humans are diverse and communications to engage us need to be inclusive. It’s no longer about talking to a group, a cohort or an imagined section of society - especially...
Building the hospital of the future
Senior Consultant Leah Carlisle explores the growing trend of virtual hospitals and what it takes to develop a holistic digital ecosystem centered on the ultimate patient experience....
Why people join a clinical trial
To understand why people decide to take part in clinical trials, you first need to understand how people make decisions....