Please login to the form below

Not currently logged in
Email:
Password:

AstraZeneca/Moderna’s mRNA treatment for heart failure looks promising

The therapy – an mRNA-encoding vascular endothelial growth factor – looks promising for patients undergoing coronary artery bypass surgery

AstraZeneca

After eight years of collaboration on mRNA-based therapeutics, AstraZeneca and Moderna have announced promising, early results for their candidate therapy AZD8601.

In the phase 2b EPICCURE trial, AZD8601 – an mRNA-encoding vascular endothelial growth factor (VEGF-A) – was injected directly into the heart muscle of patients who were undergoing elective coronary artery bypass surgery (CABG) surgery.

The trial met its primary endpoint of safety and tolerability in patients with heart failure and ‘a positive trend’ in clinical endpoints. However, only 11 patients were enrolled, so far more research is needed.

VEGF-A is important in the formation of new blood vessels and has been shown to stimulate a pathway that may contribute to the repair and regeneration of the heart.

Heart failure, which affects more than 60 million people worldwide, is a chronic disease where half of patients die within five years of diagnosis.

“Over one billion heart cells can be lost during a heart attack,” said Mene Pangalos, head of biopharmaceuticals R&D at AstraZeneca. “These early results indicate the potential of mRNA therapeutics in stimulating VEGF-A production to provide reparative and disease-modifying options for patients with heart failure and other ischaemic vascular diseases.”

Moderna CEO Stéphane Bancel called mRNA “a compelling therapeutic modality”, citing its ability to “act locally and transiently”. He continued: “The results presented today are a result of pushing new boundaries in the treatment of cardiovascular and other ischaemic vascular diseases and address serious unmet needs with the goal of improving patients’ lives.”

While mRNA technology has been in the headlines due to the Pfizer/BioNTech and Moderna COVID-19 vaccines, these results show that the approach has a wider potential.

Messenger RNA (mRNA) is responsible for carrying genetic instructions from the DNA that cells use to produce proteins, which direct the body’s biological functions. Moderna’s pioneering mRNA therapeutics are designed to trigger the cellular machinery to produce specific proteins. It is believed that AZD8601 enables the delivery of mRNA instructions to spur the production of VEGF-A protein.

AstraZeneca and Moderna signed their first agreement in 2013 aimed at discovering, developing and commercialising mRNA therapeutic candidates in a range of therapeutic areas, including cardiovascular, metabolic and renal diseases as well as selected cancer targets.

Article by
Hugh Gosling

17th November 2021

From: Research

Share

Tags

Subscribe to our email news alerts

Featured jobs

PMHub

Add my company
M3 (EU)

M3 has over 20 years’ experience in building online doctor communities. M3 is the world’s largest network of verified doctors...

Latest intelligence

Flu
Influenza – the risk to vulnerable populations
Why we can't get complacent about flu vaccination...
dementia
Alzheimer’s Research UK highlights socio-economic inequalities in dementia risk
The charity aims to improve the number of women participating in dementia research and grow awareness of dementia risk factors...
Data security
Concerns about data security are building a strong case for clinical mobility in EMEA
Electronic medical records have transformed the storage of sensitive information but how can the healthcare sector continue to protect patient and staff data?...