Please login to the form below

Not currently logged in
Email:
Password:

Breast cancer drug shows potential

Cyclacel Pharmaceuticals has announced its drug, seliciclib has shown positive results in treating breast cancer cells resistant to hormone therapy

Cyclacel Pharmaceuticals has announced the results of a study involving its drug, seliciclib (CYC202 or R-roscovitine) which has shown positive results in treating breast cancer cells resistant to hormone therapy.

The study, published in Clinical Cancer Research, a journal of the American Association for Cancer Research, showed that seliciclib, an oral inhibitor of multiple cyclin-dependent kinases (CDKs), was able to reverse resistance to the inhibitor letrozole, and killed breast cancer cells insensitive to letrozole's effects.

Letrozole is a common treatment for breast cancer in postmenopausal women, reducing the risk of early metastasis in women with estrogen receptor–positive breast cancer, and regulating the development of potentially cancerous cells.

Approximately three out of four women suffering from breast cancer after menopause have cancers that express the hormonal receptors for estrogen and progesterone and are offered treatment with such inhibitors as letrozole.

Over time though, breast cancer cells develop resistance to these inhibitors and the therapy becomes ineffective.

"Resistance to aromatase inhibitors, such as letrozole, is a major challenge for the long-term management of hormone receptor positive breast cancer," said chief scientist with Cyclacel, Professor David Glover.

"The data published in Clinical Cancer Research are encouraging as they show that seliciclib can kill resistant breast cancer cells by targeting a form of cyclin E that is a major cause of the resistance. This is further evidence that seliciclib's unique mechanism of action can be effective against certain cancer cells, such as breast and lung cancer, that fail to respond to standard cancer treatments."

Seliciclib is currently being evaluated in the APPRAISE trial, a phase IIb randomised, double-blinded, placebo-controlled study, as a treatment in patients with non-small cell lung cancer (NSCLC) who failed at least two prior therapies and in a randomised phase II study as a single agent in patients with nasopharyngeal cancer.

18th February 2010

Share

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
CSafe Global

CSafe Global is the only global provider of a full line of cold chain solutions and is the world’s largest...

Latest intelligence

Diversity in clinical trials: looking back at our 2021 blogs
In this blog, we look back at the Innovative Trials' Equality & Diversity (E&D) committee blogs across 2021...
What does the future hold for Light-chain Amyloidosis?
Recent advances in the understanding and treatment are reforming pharma’s approach to the management of this rare disease. With a new standard of care rapidly developing, what does the landscape...
Webinar:
Securing a future for telehealth with immersive market research insights...