Novartis is set to cut around 550 jobs as it restructures operations at its Horsham, UK, facility.
There are currently about 950 staff working at the site, with the number set to be reduced to around 400 over the next two years.
The company said the proposals are subject to an employee consultation and final board approval.
Sue Webb, general manager, UK & Ireland and country president, said: "Novartis is continuously evaluating its resource allocation to ensure that the organisation is highly flexible and able to proactively adapt to external challenges which best meet the needs of its customers.
"With significant changes in healthcare systems aimed to contain or cut cost, this critical assessment and the subsequent potential changes to the Novartis UK organisation are key to maintain significant investment in innovative drugs and our research efforts in the UK."
The site is shared by: Novartis Pharmaceuticals, Novartis Institutes for BioMedical Research (NIBR), and Novartis Consumer Health.
The news follows Pfizer's decision to close its facility in Kent, with the loss of 2,400 jobs.
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