Please login to the form below

Not currently logged in
Email:
Password:

Dendreon wins IQWiG U-turn for its immunotherapy Provenge

New data for its troubled cancer drug convinces German HTA body of its added benefit

IQWiG door 

Dendreon's prostate cancer immunotherapy Provenge is now being backed by IQWiG just months after the German health technology assessor was poised to reject the treatment.

Provenge (sipuleucel-T) was approved in Europe in 2013 for men with metastatic prostate cancer who have few or no symptoms and do not yet require chemotherapy. 

The German Institute for Quality and Efficiency in Health Care (IQWiG) had already assessed the drug, saying in January this year that it had “no added benefit” when compared to similar treatments.

But since then Dendreon has submitted more data to make the case for the cost-effectiveness of its drug, which showed it could increase overall survival in some patients. 

With the new data sets, IQWiG now believes that there is added benefit with Provenge compared to other medicines, but the extent is “non-quantifiable”, according to the Institute. 

It is, however, now happy to recommend it and Germany's G-BA - the body that has the final say on whether the drug will make be reimbursed in the country - will make a final decision this quarter. 

Provenge problems

Dendreon was the first pharma company in the world to market a cancer immunotherapy when Provenge gained FDA approval in 2010.

This began a small revolution in cancer care as, over the next four years, a host of new oncology medicines that 'teach' the body to kill tumours began gaining approval, with BMS and Merck & Co now marketing blockbuster medicines using this mechanism of action.

But Dendreon has been left behind as manufacturing issues blighted the firm's sales potential, and it has failed to convince key HTA bodies - most notably NICE - of the drug's cost effectiveness. 

This is largely to do with Provenge's price tag, which for a full dose in the UK is just under £50,000 per patient. 

The drug has also come under pressure from new prostate cancer pills, such as Janssen's Zytiga (abiraterone acetate), which are cheaper and easier for patients to take.

But Dendreon will be pleased with this decision from IQWiG, as it is now set to gain access to Europe's largest pharma market.

Article by
Ben Adams

24th March 2015

From: Sales

Share

Tags

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Iguazu

Iguazu Ltd is a digital healthcare agency, delivering tactical and innovative solutions. WHAT WE DO We are Closed Loop Marketing...

Latest intelligence

Health literacy in the time of COVID-19
In a time when much of the media’s focus is on the ongoing COVID-19 pandemic and the differences in vaccination rates between various regions, countries, and socioeconomic groups, improving health...
Rare thoughts & outcomes - navigating pathways to better outcomes in rare
...
How to pick the perfect training program for your healthcare professionals
You know your team needs training. But not all training providers and programs are created equal. Last week, we shared the benefits of working with specialist learning and development (L&D)...