Please login to the form below

Not currently logged in
Email:
Password:

PureTech adds potential IBD therapeutic to pipeline after buying out Alivio Therapeutics

Alivio is developing therapeutic candidates for a number of inflammatory disorders

PureTech Health has acquired all remaining shares of its founded entity Alivio Therapeutics, five years after launching the company, adding a number of anti-inflammatory therapeutic candidates to its pipeline as a result.

Alivio is developing therapeutic candidates for a number of inflammatory disorders, including inflammatory bowel disease (IBD).

Now that PureTech has acquired the remaining 22% of outstanding shares  in Alivio, it will fully integrate these candidates into its wholly owned development pipeline.

Alivio’s technology platform can combine a biologic agent and a small molecule drug into a single oral dosage form, potentially offering an enhanced treatment for certain inflammatory diseases by maximising efficacy and minimising toxicity.

Among these candidates is LYT-500, an orally-administered therapeutic candidate currently in development for the treatment of IBD.

LYT-500 is comprised of two active agents, designed to selectively act on the inflamed tissues while reducing their impact on normal tissues. The candidate contains a combination of IL-22 and an anti-inflammatory drug, in a bid to address the two key underlying causes of IBD pathogenesis and progression.

In addition to LYT-500, PureTech will also add LYT-503/IMB-150 to its pipeline, a potential non-opioid treatment for interstitial cystitis or bladder syndrome which is currently being developed in collaboration with Ibrium Therapeutics.

“PureTech founded Alivio alongside leading scientists Jeffrey Karp, professor of medicine at Brigham and Women’s Hospital and Robert Langer, David H. Koch Institute Professor at MIT to pioneer a novel strategy to more effectively treat inflammatory disorders through highly targeted immunomodulation at the site of disease,” said Daphne Zohar, founder and chief executive officer of PureTech.

"This promising approach fits well within our wholly owned pipeline and we will be able to leverage our strength in immunology and related technologies as we progress therapeutic candidates to potentially treat inflammatory diseases,” she added.

Elsewhere in its pipeline, PureTech has therapeutic candidates in various stages of development for the treatment of a range of conditions and diseases, including idiopathic pulmonary fibrosis, respiratory complications and related sequelae of Long COVID, breast cancer-related upper limb secondary lymphedema and metastatic solid tumours.

Article by
Lucy Parsons

17th June 2021

From: Research, Sales

Share

Tags

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
Accession

Accession was a born from a passion and a vision. A passion to harness the power of market access to...

Latest intelligence

JulAug cover image
The Chronicles of Pharma: a creative review of pharma’s journey to omnichannel
Chris Ross conducts a literary-inspired review of pharma’s pursuit of communications excellence...
The key to psoriasis innovation? Dispelling the shadow of the JAK inhibitor
Powerful therapies that can improve skin clarity dominate the psoriasis landscape, so why are most patients stuck in a cycle of ineffective topicals? Fishawack Health explores the market and reveals...
Virtual Speaker Program: A Customer Story
Learn how we helped our client develop a virtual speaker program and roll out a series of regional peer-to-peer education sessions....