Please login to the form below

Not currently logged in
Email:
Password:

Servier expands breast cancer partnership

Will build on deal with French cancer research centre Curie-Cancer

Servier expanded its research partnership with French cancer research centre Curie-Cancer to encompass work on identifying new therapeutic targets to treat triple negative breast cancer.

It's a form of the disease that does not express oestrogen, progesterone or HER2, receptors that can stimulate growth of the cancer and for which there are currently specific treatments available, including hormone therapy and Roche's Herceptin (trastuzumab).

However, there are no targeted treatments for triple negative breast cancer, which is thought to account for 15 per cent of all breast cancers, limiting patient treatment options to surgery, chemotherapy and radiotherapy.

To counter this, Servier has been working with Curie-Cancer since 2005, when the two bodies agreed to pool together their expertise to identify potential drug targets specific to triple negative breast cancer using Curie-Cancer's collection of breast cancer samples.

According to Servier, the partnership has led to the discovery of "a number of very promising leads", including kinase TTK/MPS1, an enzyme involved in cell cycle regulation.

With this prospect in the pipeline, Servier and Curie-Cancer have agreed to extend their collaboration for another three years, sharing any intellectual property resulting from their work.

Emmanuel Canet, president of R&D at Servier, said: “Our decision to extend the partnership for a further three years was inspired by these highly encouraging results, the need to look at the other results obtained in more depth and the desire to explore other potential leads.”

Other drugs in development for triple negative breast cancer include Abbvie's veliparib, which is in phase II development, and Merck's highly promising MK-3475, which has shown potential in a number of indications.

Some companies have struggled in the area, however, including Sanofi, which saw its investigational drug iniparib fail to meet trial targets in 2011.

Article by
Thomas Meek

30th January 2014

From: Research

Share

Tags

COVID-19 Updates and Daily News

Featured jobs

PMHub

Add my company
TRIDUCIVE

Triducive are a strategic healthcare consultancy who produce communications that have practical, dynamic application that encourage behaviour change because of the...

Latest intelligence

How innovating study sites can improve patient recruitment efficiency
There are so many ways that clinical trials have innovated over the last few years. There is now a larger focus on making trials more patient-centric, more virtualised, and more...
PME-MAY21-Cover
Avoiding A Series of Unfortunate Events: launch lessons from lockdown
Chris Ross takes a novel look at launch excellence through the lens of COVID-19 and explores how pharma’s launch leaders are rewriting the story...
6 reasons patients drop out of clinical trials and 6 ways to fix it
If you’ve successfully recruited patients for your clinical trial, but one by one, they begin to drop out, then this information could be for you....