Please login to the form below

Not currently logged in
Email:
Password:

SMC approves Glivec for GIST

Glivec has been approved for use within NHS Scotland as adjuvant post-surgery therapy to delay the recurrence of GIST

The Scottish Medicines Consortium (SMC) has approved the use of Novartis' imatinib (Glivec/Gleevec) within NHS Scotland for use in the adjuvant treatment of adults who are at a high risk of recurrence following complete resection of Kit (CD117)-positive gastrointestinal stromal tumours (GIST).

The drug advice notes that imatinib, given for a period of one year, significantly improved the estimated one year recurrence-free survival compared with placebo and was associated with an increase of 16.4 months in median time to recurrence in patients at high risk of relapse following resection. The economic case was demonstrated for a one-year adjuvant treatment duration only.

The SMC's decision is in contrast to the National Institute for Health and Clinical Excellence's (NICE) decision to reject the drug for use in England and Wales in August.

NICE stated that although there is evidence that giving imatinib as adjuvant post-surgery therapy can delay the recurrence of GIST, there is a lack of evidence relating to the clinical effectiveness of imatinib, in particular whether adjuvant imatinib extends life expectancy, how long treatment should be continued and whether resistance to imatinib develops.

15th September 2010

From: Healthcare

Share

Subscribe to our email news alerts

Featured jobs

PMHub

Add my company
Medscape Medical Affairs

Medscape Medical Affairs enables all medical affairs professionals to take a more strategic leadership role, and maximize the impact of...

Latest intelligence

Lifting the fog to help Clinical Labs navigate IVDR 2022
In Vitro Diagnostic Regulation (IVDR 2022) was on the horizon: a new regulatory basis for laboratories to adhere to regarding their diagnostic equipment and tests. BD wanted to let their...
Empowering adolescents to manage emotional and mental health issues
1 in 10 UK children suffer with a mental health issue and alarmingly as many as 70% of these don’t receive the proper support they need. That’s why The Anna...
Reframing rare to increase earlier diagnosis of Gaucher Disease
Sanofi Genzyme wanted to reach haematologists; the specialist physicians most likely to encounter patients with Gaucher Disease prior to diagnosis. The problem? Gaucher Disease is considered very rare and its...