Please login to the form below

Brain tumour awareness month: giving research a more humane face

Did you know that March is Brain Tumour Awareness Month? With brain tumour cases rising, funds are urgently needed to help find a cure for this swift, relentless killer.

Brain tumours can affect anyone at any age, including children – and they’re more common than you might think.

According to the Brain Tumour Research Report© on National Research Funding, someone in the UK is diagnosed with a brain tumour every two hours. And yet, only 1% of the national spend on cancer research is allocated to this devastating disease.

Brain tumours, it seems, are not prioritised for cancer research funding, despite the fact that they are the main cause of cancer deaths in children and people under 40; only 12% of brain tumour patients survive for 5 years or more.

Why this neglect? One reason, put forward by a group of specialists, is that brain tumours are “too complex, too variable, and too low profile because they lack a vocal patient group”*. Nevertheless, there are green shoots of hope for the future of brain tumour research.

During this awareness month, we’re delighted to share news of the breakthrough brain tumour research Animal Free Research UK has been funding: experts in neuro-oncology Professor Geoff Pilkington, Dr Zaynah Maherally and their team have been developing the first cutting-edge, animal free, 3D model of the blood-brain barrier.

Their research could find more effective ways of treating patients, including children, who suffer from brain tumours.

3D Model of the blood-brain barrier

The blood-brain barrier is the term given to the blood vessels that protect the brain from potentially harmful substances, such as bacteria and viruses. While this barrier is crucial for survival, it presents a challenge for researchers: they need some substances to be able to get through, such as drugs to treat brain tumours. Many drugs that could hold the potential to cure or slow the progress of tumours can’t access the brain, as they are blocked by the blood-brain barrier.

For this reason, Professor Pilkington and his team have engineered the most sophisticated in vitro blood-brain barrier reported to date. He explains “It’s comprised wholly of human cells and proteins, thus reflecting the biological features of the human brain far more accurately than other animal experiments and in vitro models.”

Before the development of animal-replacement research techniques, animals such as mice and zebrafish have been used as models to help scientists find ways across the blood-brain barrier.** However, by developing new 3D models that replicate human tissue, it is possible to save both human and animal lives.  As 90% of drugs tested in animals still fail in humans, investing in alternatives could also help to advance science and accelerate breakthroughs.

Professor Pilkington explains: “We believe human studies are essential. When we grow cells in human serums, we get different proteins expressed – we get different behaviours of cells, different structures of the cells and so on. So it’s really important that we grow cells using human proteins, human serums and human cells, because that will reflect what’s actually going on in the brain.”

Thanks to this 3D blood-brain barrier model, it’s possible to study a more accurate representation of the human brain and advance the treatment of brain tumours. Science keeps evolving, and the future face of science could be animal-free, and more humane. Animal-free science has already shown positive outcomes, and will surely lead to further quantum leaps.

Animal Free Research UK funds projects that develop human methods and non-animal technologies to study human disease. If you’d like to donate to support brain tumour research and help save animals from suffering, click here.

To find more about Professor Pilkington and Dr Zaynah Maherally’s 3D model, click here.

About 11 London

11 London is an advertising and communications agency, based in West London. We work in the areas of health and humanity - with organisations, brands or products that improve or prolong life. To learn more about 11 London, please contact:

matthew.hunt@11-london.com

**Sources:

https://www.bmj.com/content/349/bmj.g5966

http://genesdev.cshlp.org/content/32/7-8/466.full

23rd March 2021

Share

Tags

Company Details

11 London

020 3761 2930

Contact Website

Address:
Unit 10 Turnham Green Mews
Turnham Green Terrace
Chiswick
London
W4 1QU

Latest content on this profile

Who cares… about great healthcare creative?
Prestigious awards for healthcare communications tend to be dominated by the big network agencies and their offshoots. And the work deserves the wins. Imaginative, innovative, powerful, arresting – it’s all of that. But is it inspiring the rest of us to emulate these creative heights? And if not, why not?
11 London
Maxwellia works with 11 London for social promotion of first ever OTC contraceptive pill
We’re excited to announce that we are now working with pioneering British pharma company Maxwellia to help launch Lovima®, a contraceptive pill to be available in pharmacies without the need for a doctor’s prescription – for the first time in UK history.
11 London
‘Funny’, ha ha: how neurodiverse comedy can help us understand each other
Ever since Hans Asperger showed cartoons to his ‘little professors’ and they didn’t laugh, it was believed that people with autism lacked a sense of humour. Today, a new wave of ‘neuro-funky’ comedians are busting myths, shining a light on their reality, and challenging us all to communicate in ways that make everyone feel included.
11 London
Brain tumour awareness month: giving research a more humane face
Did you know that March is Brain Tumour Awareness Month? With brain tumour cases rising, funds are urgently needed to help find a cure for this swift, relentless killer.
11 London
The imperfect art of sustainable communications
Scanning the papers this last week, we’ve seen a welcome departure from wall-to-wall gloom –and very real signs of ‘Reasons To Be Cheerful’.The economy, we’re told, might not be such a basket case after all: in fact, we should be looking at a recovery later this year. Whilst we might have been dubbed ‘Plague Island’ by some, we’re now –thanks to the vaccines – more of a speedboat than a tanker. And with the UK stepping up as G7 president this year, hosting COP26 in November, and being the fastest country in the G20 to decarbonise its economy since 2000, all eyes are on us - for the right reasons.
11 London
Migraine-friendly colours for the home
You may not realise it, but colour impacts migraines. 11 London worked with Teva Pharmaceuticals UK, Dulux Paints and the National Migraine Centre to test this theory among 1,200 migraine sufferers and the results were amazingly consistent.
11 London