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BACE1 inhibitor

This page shows the latest BACE1 inhibitor news and features for those working in and with pharma, biotech and healthcare.

Biogen and Eisai drop Alzheimer’s drug elenbecestat

Biogen and Eisai drop Alzheimer’s drug elenbecestat

The failure of elenbecestat comes on the heels of Amgen and Novartis also  abandoning phase 2/3 studies of BACE1 inhibitor CNP520 (umibecestat) after some participants taking the drug saw their ... BACE inhibitor drugs target the beta amyloid cleaving

Latest news

  • Amgen and Novartis abandon Alzheimer’s drug after worsening symptoms Amgen and Novartis abandon Alzheimer’s drug after worsening symptoms

    Latest BACE inhibitor to run into trouble. Amgen, Novartis and Banner Alzheimer's Institute are to halt trials of their BACE1 inhibitor CNP520 (umibecestat) after some participants taking the drug saw ... The loss of CNP520 leaves just one major BACE

  • Eisai to tackle dementia in new US research facility Eisai to tackle dementia in new US research facility

    The area could very well be a gamble for the Japanese group as rivals AstraZeneca and Eli Lilly - who partnered up to look into BACE1 inhibitor candidates in Alzheimer’s - dropped ... Merck &Co has also seen failure with its BACE1 inhibitor verubecestat

  • Off BACE: AZ/Lilly drop Alzheimer’s drug lanabecestat Off BACE: AZ/Lilly drop Alzheimer’s drug lanabecestat

    The demise of the BACE1 inhibitor – also known as AZD3293/LY3314814 – adds to the litany of failures among drugs intended to treat Alzheimer’s, and specifically those trying to slow down ... A few weeks ago, Merck &Co abandoned its BACE1 inhibitor

  • Another Alzheimer's bust as Merck & Co stops verubecestat study Another Alzheimer's bust as Merck & Co stops verubecestat study

    Late-stage BACE1 failure could be an ominous signal for Eli Lilly/AZ and Biogen/Eisai. ... Merck &Co has abandoned the phase III trial of its BACE1 inhibitor verubecestat in Alzheimer’s in what could be an ominous signal for Eli Lilly/AstraZeneca and

  • Alzheimer's disease pipeline takes multiple hits Alzheimer's disease pipeline takes multiple hits

    MK 8931 (Merck &Co.) is a potential first-in-class, potent Aß precursor protein cleaving enzyme (BACE1) inhibitor. ... LY 2886721 (Lilly) is another BACE1 inhibitor that was in phase I/II development in the US, Japan and some EU countries, but the phase

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  • Interview: Mike Hutton, Lilly Interview: Mike Hutton, Lilly

    Lilly has not been immune from such difficulties. Its BACE1 inhibitor LY 2886721 and amyloid-beta treatment semagacestat also failed, the latter in a large phase III clinical trial.

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