This page shows the latest bempedoic acid news and features for those working in and with pharma, biotech and healthcare.
The phase 3 CLEAR trial was designed to evaluate whether treatment with Nexletol (bempedoic acid) could reduce the risk of cardiovascular events in patients who are at high risk for cardiovascular
Bempedoic acid is described as a first-in-class ATP citrate lyase (ACL) inhibitor that inhibits cholesterol synthesis in the liver. ... The company has also filed bempedoic acid in Europe, as well as a combination pill with ezetimibe, filed with both the
US. However, both these drugs are facing the threat of competition from new oral therapies such as Esperion’s bempedoic acid, which could be filed for approval in early 2019, and
Esperion has seen almost a fifth of the value wiped off its shares as a phase III trial of its atherosclerosis candidate bempedoic acid revealed a three-fold increase in deaths ... The pivotal trial, which was comparing bempedoic acid to placebo given on
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Esperion planned to launch its lipid-lowering agent, Nexletol (bempedoic acid), in March 2020 before releasing the combination therapy, Nexlizet (bempedoic acid/ezetimibe), in July.
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