This page shows the latest EGFR inhibitor news and features for those working in and with pharma, biotech and healthcare.
NSCLC) to receive the Tagrisso/chemotherapy combination or the EGFR-tyrosine kinase inhibitor alone. ... Approximately 10% to 15% of NSCLC patients in the US and Europe have EGFRm NSCLC, with this patient population particularly sensitive to treatment
lazertinib for patients with non-small cell lung cancer (NSCLC) and epidermal growth factor receptor (EGFR) mutations. ... The phase 1b/2 CHRYSALIS-2 study is an ongoing clinical trial evaluating Rybrevant in combination with lazertinib, a
kinase inhibitor, in patients with advanced EGFR-mutated (EGFRm) NSCLC with MET alterations whose disease progressed on first-line Tagrisso. ... OReO, the first phase 3 trial to evaluate retreatment with a PARP inhibitor in resistant disease.
AstraZeneca’s (AZ) third-generation EGFR tyrosine kinase inhibitor (TKI) Tagrisso has been approved to treat early-stage EGFR mutated non-small cell lung cancer (NSCLC) in the EU. ... NSCLC. Janssen assessed the investigational drug in combination
In 2020, oncology growth was up by 23% to $11.45bn, with the top-selling product being AZ’s EGFR-tyrosine kinase inhibitor Tagrisso (osimertinib). ... AZ also reported significant sales growth for checkpoint inhibitor Imfinzi (durvalumab) and PARP
Braftovi (encorafenib) combined with has been recommended Merck KGaA’s EGFR-targeting antibody Erbitux (cetuximab) has been recommended as a second-line treatment for BRAF-positive metastatic colorectal cancer (mCRC). ... The trial also demonstrated
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EGFR-TK) inhibitor, which has so far been approved in non-small cell lung cancer, albeit after a much-delayed, stop-start regulatory journey. ... If approved, the drug would complement AZ's other NSCLC drug, Iressa, which is approved in NSCLC patients
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