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HIF-PHI

This page shows the latest HIF-PHI news and features for those working in and with pharma, biotech and healthcare.

Astellas files new application for expanded use of roxadustat in Japan

Astellas files new application for expanded use of roxadustat in Japan

Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). In contrast to ESAs, HIF-PIH inhibitors stimulate endogenous production of erythropoietin, the protein on which ESAs are based.

Latest news

  • GSK files anaemia drug daprodustat in Japan, its first market GSK files anaemia drug daprodustat in Japan, its first market

    Daprodustat – a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) – will be distributed in Japan by Kyowa Kirin if it gets the nod from the Ministry of Health, Labour and Welfare ... In contrast, HIF-PHI drugs stimulate endogenous

  • China first market to approve AZ’s kidney drug roxadustat China first market to approve AZ’s kidney drug roxadustat

    Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI) and according to AZ’s chief medical officer Sean Bohen is the first oral drug in this class, as well ... In contrast,   HIF-PH inhibitors stimulate endogenous production

  • GSK starts late-stage trials of daprodustat GSK starts late-stage trials of daprodustat

    CKD)  . The orally-active hypoxia-inducible prolyl hydroxylase inhibitor (HIF-PHI) could be a $450m product by 2020, according to Credit Suisse forecasts, and is one of a block of new ... administration.". GSK is in a race to market with other HIF-PHI

  • AZ inks $815m deal for FibroGen anaemia drug AZ inks $815m deal for FibroGen anaemia drug

    The drug is an orally administered small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PHI) and offers an alternative to injectable treatments based on erythropoietin (EPO), which account for

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